益气法治疗慢性心衰疗效观察及对NT-proBNP、maxEav、LVEF的影响

Curative Effect Observation on Method of Replenishing Qi for Chronic Heart Failure and Its Effect on NT-proBNP,maxEav and LVEF

目的:观察益气法治疗慢性心力衰竭的疗效及其对脑钠肽前体(NT-pro BNP)、最大心肌劲度(max Eav)、左室射血分数(LVEF)的影响。方法:将心气虚证慢性心力衰竭患者120例,按随机数字表法分为治疗组与对照组各60例;所有患者均接受西药常规规范化治疗,治疗组加用益气法(中药)治疗,疗程均为4周;疗程结束后统计2组中医证候积分变化,并检测治疗前及治疗后2组患者NT-pro BNP、max Eav、LVEF水平。结果:治疗后总有率治疗组为90.0%,对照组为75.0%,2组比较,差异有统计学意义(P <0.05)。治疗后2组中医证候积分较治疗前明显降低(P <0.05);治疗后2组间比较,治疗组改善较对照组更显著,差异亦有统计学意义(P <0.05)。治疗后2组NT-pro BNP水平较治疗前降低(P <0.05),max Eav、LVEF水平较治疗前升高(P <0.05);治疗后2组间比较,治疗组上述各项指标改善优于对照组(P <0.05)。治疗后2组患者血尿酸水平均较治疗前升高(P <0.05);但治疗组患者血尿酸水平低于对照组(P <0.05)。结论:益气法联合西药常规规范化治疗慢性心力衰竭临床疗效显著,可降低患者NT-pro BNP水平,提高患者LVEF、max Eav水平,从而改善心功能。

Objective： To observe the curative effect of the method of replenishing qi for chronic heart failure and its effect on pro-brain natriuretic peptide（NT-proBNP）, maximum myocardial stiffness（maxEav） and left ventricular ejection fraction（LVEF）.Methods：Divided 120 cases of patients with chronic heart failure into the treatment group and the control group according to random number table method,60 cases in each group. The two groups received routine and standardized western medicine for treatment,while the treatment group additionally received Chinese herbal medicine of the method of replenishing qi. The two groups were treated for four weeks. After treatment, recorded the changes of scores of Chinese medicine syndromes in the two groups and detected levels of NT-proBNP, maxEav and LVEF in the two groups before and after treatment. Results： After treatment, the total effective rate was 90.0% in the treatment group and was 75.0% in the control group,the difference being significant（P〈0.05）. After treatment,scores of Chinese medicine syndromes in the two groups were obviously decreased when compared with those before treatment（P〈0.05）; the improvement in the treatment group was better than that in the control group,the difference being significant（P〈0.05）. After treatment,levels of NT-proBNP in the two groups were decreased when compared with those before treatment（P〈0.05）,while levels of maxEav and LVEF were increased when compared with those before treatment（P〈0.05）;the improvement of the above indexes in the treatment group was better than that in the control group（P〈0.05）. After treatment,levels of uric acid in the two groups were increased when compared with those before treatment（P〈0.05）,while the level of uric acid in the treatment group was lower than that in the control group（P〈0.05）. Conclusion： The therapy of the method of replenishing qi for chronic heart failure combined with routine and standardized western medicine,has significant clinical effect,which can reduce the level of NT-proBNP and improve levels of maxEav and LVEF so as to improve the cardiac function.