胆舒胶囊联合左氧氟沙星治疗慢性胆囊炎临床观察

Clinical Observation of Danshu Capsules Combined with Levofloxacin Tablets for Chronic Cholecystitis

目的:观察胆舒胶囊联合左氧氟沙星片治疗慢性胆囊炎的临床疗效。方法:选取300例慢性胆囊炎患者为研究对象,按随机双盲法分为实验组与对照组各150例。2组均予以消炎、抗感染、维持水电解质平衡等常规治疗,在此基础上,对照组给予左氧氟沙星片治疗,实验组给予胆舒胶囊联合左氧氟沙星片治疗,2组均连续治疗14天。治疗后比较2组临床疗效,观察患者治疗前后血清细胞因子水平的变化及不良反应发生情况。结果:实验组总有效率96.67%,对照组总有效率74.67%,2组比较,差异有统计学意义(P <0.01)。治疗后,2组肿瘤坏死因子-α(TNF-α)、β-内啡肽(β-EP)和血清超氧化物歧化酶(SOD)水平均较治疗前降低(P <0.05),血清丙二醛(MDA)水平均较治疗前升高(P <0.05);实验组TNF-α、β-EP、MDA、SOD水平与对照组比较,差异均有统计学意义(P <0.05)。实验组不良反应发生率7.33%,对照组不良反应发生率6.67%,2组比较,差异无统计学意义(P>0.05)。结论:胆舒胶囊联合左氧氟沙星片治疗慢性胆囊炎临床疗效显著,可有效调节患者体内的相关细胞因子水平,且用药安全。

Objective：To observe the clinical effect of Danshu capsules combined with levofloxacin tablets for chronic cholecystitis.Methods：Selected 300 cases of patients with chronic cholecystitis as study subjects,and divided them into the experiment group and the control group by randomized double blind method, 150 cases in each group. Both groups received such routine treatment as diminishing inflammation,anti-infection and keeping water-electrolyte balance,and based on the routine,the control group additionally received levofloxacin tablets while the experiment group additionally received Danshu capsules combined with levofloxacin tablets. The treatment for both groups lasted for 14 days. After treatment,compared the clinical effect in both groups,and observed the changes of levels of cytokines and occurrence of adverse reactions in serum of patients before and after treatment. Results：The total effective rate was 96.67% in the experiment group and 74.67% in the control group,difference being significant（P〈0.01）. After treatment,levels of tumour necrosis factor-α（TNF-α）,β-endorphin（β-EP） and serum superoxide dismutase（SOD） were lower than those before treatment（P〈0.05）,and the level of serum malondialdehyde（MDA） was higher than that before treatment（P〈0.05）;comparing the levels of TNF-α, β-EP, MDA and SOD in the experiment group with those in the control group, there were significant differences being found（P〈0.05）. The incidence of adverse reactions was 7.33% in the experiment group and 6.67% in the control group, difference being insignificant（P〉0.05）. Conclusion：Danshu capsules combined with levofloxacin tablets has significant clinical effect in treating chronic cholecystitis,which can effectively regulate the levels of related cytokines with medication safety.