滋肾安胎汤联合黄体酮注射液治疗先兆流产临床观察

Clinical Observation of Zishen Antai Tang Combined with Progesterone Injection for Threatened Abortion

目的:观察滋肾安胎汤联合黄体酮注射液治疗先兆流产肾虚证的临床疗效。方法:选取98例先兆流产患者为研究对象,按随机数字表法分为治疗组和对照组,每组49例。对照组予黄体酮注射液肌肉注射,治疗组在对照组基础上加用滋肾安胎汤,2组均连续治疗2周。比较2组临床疗效、肾虚证主症积分及妊娠结局,检测2组血清孕酮(P)、人绒毛膜促性腺激素(HCG)和雌二醇(E_2)水平。结果:治疗组总有效率93.88%,高于对照组的77.55%,差异有统计学意义(P <0.05)。治疗后,2组肾虚证主症(阴道出血、小腹坠痛、腰酸痛、两膝酸软)评分均较治疗前降低(P <0.01);与对照组比较,治疗组上述症状评分降低更显著(P <0.01)。治疗组正常妊娠率89.80%,高于对照组的69.39%,差异有统计学意义(P <0.05)。治疗后,2组血清P、HCG和E_2水平均明显提高(P <0.01);治疗组血清P、HCG和E_2水平均高于对照组(P <0.01)。结论:滋肾安胎汤联合黄体酮注射液治疗先兆流产肾虚证疗效确切,可有效调节患者体内P、HCG和E_2水平,提高正常妊娠率。

Objective： To observe the clinical effect of Zishen Antai tang combined with progesterone injection for threatened abortion with kidney deficiency syndrome. Methods： Selected 98 cases of patients with threatened abortion as study subjects, and divided them into the treatment group and the control group randomly,49 cases in each group. The control group received progesterone injection by intramuscular injection,while the treatment group additionally received Zishen Antai tang. The treatment for both groups lasted for 2 weeks. Compared the clinical effect,main symptom scores of kidney deficiency syndrome and pregnancy outcome in both groups. Detected the levels of progesterone（P）, human chorionic gonadotropin（HCG）, and estradiol（E2） in serum of both groups.Results： The total effective rate was 93.88% in the treatment group, which was higher than control group 77.55%, difference being significant（P〈0.05）. After treatment,main symptom scores of kidney deficiency syndrome（vaginal bleeding,bearing-down pain in the lower abdomen, soreness and pain of waist, debility in knees） in both groups were lower than those before treatment（P〈0.01）.Comparing with the control group,each symptom score above in the treatment group was decreased more significantly（P〈0.01）. The normal pregnancy rate was 89.80% in the treatment group,being significantly higher than 69.39% in the control group,difference being significant（P〈0.05）. After treatment,the levels of P,HCG and E2 in both groups were all evidently increased（P〈0.01）;the levels of P, HCG and E2 in the treatment group were all higher than those in the control group（P〈0.01）. Conclusion： Zishen Antai tang combined with progesterone injection has definite effect in treating threatened abortion with kidney deficiency syndrome, which can regulate the levels of P,HCG and E2 in the body of patients and promote the normal pregnancy rate.