非小细胞肺癌中医证型与组织病理分型及EGFR基因的相关性研究

Research on Correlation between Chinese Medicine Syndrome Differentiation for Non-small Cell lung Cancer and histopathologic typing as well as EGFR Gene

目的:对非小细胞肺癌患者的中医证型与组织病理分型、EGFR基因的相关性进行统计分析,以发现其分布规律。方法:对非小细胞肺癌患者96例,应用SPSS统计软件对中医证型与西医组织病理分型、EGFR基因的相关性进行统计分析。结果:非小细胞肺癌不同病理类型与中医分型间存在差异(P <0.05)。腺癌中医辨证以寒湿证比例最多(46.7%),其次为虚证(24.0%);鳞癌中医辨证以气阴两虚证最多(38.1%),其次为痰热证(28.6%)。肺癌中医辨证分型与EGFR基因表达存在差异(P <0.05)。肺癌患者中EGFR阳性表达依次由痰热证、气滞血瘀证、气阴两虚证、寒湿证递增;其中寒湿证与痰热证、气滞血瘀证比较,差异均有统计学意义(P <0.05)。结论:肺癌中医证型与组织病理分型、EGFR基因表达间有一定的相关性,可以为中医辨证施治提供客观依据。

Objective： To discover the distribution law of correlation between Chinese medicine syndrome differentiation and histopathologic typing as well as EGFR gene in patients with non-small cell lung cancer by summarizing and analyzing it. Methods：Applied SPSS statistical software to analyze the correlation between Chinese medicine syndrome types and western medical histopathological types as well as EGFR gene in 96 cases of patients with non-small cell lung cancer. Results： There were significant differences being found between different pathological types and Chinese medicine types of non-small cell lung cancer（P〈0.05）. The proportion of cold-dampness syndrome in Chinese medicine syndrome differentiation for adenocarcinoma was the highest（46.7%）,followed by deficiency syndrome（24.0%）. The syndrome of qi-yin deficiency in Chinese medicine syndrome differentiation for squamous cell carcinoma was the most common one（38.1%）,followed by phlegm-heat syndrome（28.6%）. There was a significant difference being found between Chinese medicine syndrome differentiation and EGFR gene expression in lung cancer（P〈0.05）. The positive expression of EGFR in patients with lung cancer was in turn increased by phlegm-heat syndrome, qi stagnation and blood stasis syndrome,syndrome of qi-yin deficiency, and cold-dampness syndrome. Among them, there were significant differences being found in the comparisons of cold-dampness syndrome, phlegm-heat syndrome and qi stagnation and blood stasis syndrome（P〈0.05）. Conclusion：There is a certain correlation between Chinese medicine syndrome types and histopathological types as well as EGFR gene expression in lung cancer,which can provide an objective basis for the application of Chinese medicine syndrome differentiation.