银屑病患者血清IgE水平增高的Meta分析

Psoriasis and elevated serum IgE : a meta-analysis

目的:Meta分析银屑病患者血清IgE增高情况。方法:计算机检索1976年1月至2018年1月Pubmed、Embase、Cochrane Library、中国生物医学文献数据库、万方数据库及中国知网等数据库中关于银屑病患者血清IgE相关的研究文献,采用stata12.0软件进行数据分析。结果:纳入符合标准的文献共10篇,共涉及2545例研究对象,其中包含1223例银屑病患者及1322名对照,Meta分析结果显示银屑病患者血清总IgE升高所占比例高于对照组,(OR=2.85%,95%CI:2.23～3.65),差异有显著统计学意义(P<0.05)。结论:银屑病患者血清总IgE明显增高,可能与银屑病发病有关。

Objective： To analyze the elevated IgE level in the patients with psoriasis. Methods： The articles of the IgE level in the patients with psoriasis were searched in MEDLINE,EMBASE,Cochrane Library,SinoM ed,CNKI and Wanfang database from January 1976 to January 2018. The data was analyzed by Stata12.0. Results： Ten articles including 1223 cases met the criteria. Meta analysis showed the ratio of the patients with elevated serum IgE was higher than that of the controls（ OR = 2.8595%,95%CI： 2.23-3.65）,with a significant difference（ P〈0.05）. Conclusion： The level of IgE in the patients with psoriasis is increased,which means that IgE may play an important role in the pathogenesis of psoriasis.