Smad7在脂溢性角化病、日光性角化病及基底细胞癌中的表达

Expression of Smad7 in seborrheic keratosis,actinic keratosis and basal cell carcinoma

目的:检测Smad7在脂溢性角化病、日光性角化病以及基底细胞癌中的表达。方法:对脂溢性角化病、日光性角化病及基底细胞癌标本(各30例)和30例正常标本进行免疫组化染色。结果:23例脂溢性角化病标本、23例日光性角化病标本和28例基底细胞癌标本中Smad7染色阳性,阳性细胞率分别为(31.0±23.0)%,(32.7±26.3)%和(62.6±32.1)%,均显著高于正常组织的(6.7±5.0%)。结论:Samd7可能与脂溢性角化病、日光性角化病以及基底细胞癌的发病有关。

Objective： To detect the expression of Smad7 in the lesions of seborrheic keratosis,actinic keratosis,and basal cell carcinoma. Methods： The levels of Smad7 in the lesions of seborrheic keratosis,actinic keratosis,basal cell carcinoma and normal controls（ 30 lesions in each group）,were detected by immunohistochemical staining. Results： Smad7 was positive in 23 seborrheic keratosis lesions,23 actinic keratosis lesions and 28 basal cell carcinoma lesions. The positivity rates of Smad7 cells were（ 31.0±23.0） %,（ 32.7±26.3） % and（ 62.6±32.1） % respectively,which were all higher than that in the controls（ 6.7±5.0） %. Conclusion： Smad7 may play a role in the pathogenesis of seborrheic keratosis,actinic keratosis and basal cell carcinoma.