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胎盘组织中IL-37的表达及其与子痫前期发病的关系 被引量:1

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摘要 目的探讨胎盘组织白细胞介素-37(IL-37)的表达及与子痫前期发病的关系。方法选取2015年1月-2016年1月在该院治疗的子痫前期患者81例,其中轻度子痫前期患者47例(轻度组),重度子痫前期患者34例(重度组);同时选取正常妊娠孕妇50例作为对照组,采用免疫组化染色和Western Blot检测各组IL-37蛋白表达,采用RT-PCR检测各组IL-37 mRNA表达。结果重度组胎盘组织IL-37蛋白表达为(0.561±0.123),明显低于轻度组和对照组(P<0.05);轻度组胎盘组织IL-37蛋白表达为(0.658±0.116),明显低于对照组(P<0.05);重度组胎盘组织IL-37 mRNA表达为(0.540±0.103),明显低于轻度组和对照组(P<0.05);轻度组胎盘组织IL-37 mRNA表达为(0.834±0.156),明显低于对照组(P<0.05);子痫前期患者IL-37 mRNA和蛋白表达与分娩孕周无相关性(P>0.05)。结论子痫前期和正常妊娠孕妇胎盘组织均有IL-37表达,其中子痫前期患者IL-37蛋白和mRNA表达明显降低,可能参与了子痫前期的发病过程。
出处 《中国妇幼保健》 CAS 2018年第20期4753-4756,共4页 Maternal and Child Health Care of China
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