ApoM基因rs805296多态性与冠心病相关性的Meta分析

Association of rs805296 polymorphisms in ApoM gene and risk of coronary heart disease:a Meta-analysis

目的:系统评价ApoM基因rs805296多态性与冠心病相关性。方法:检索PubMed、EMbase、The Cochrane Library、中国知网、万方数据库、维普,搜集ApoM基因rs805296多态性与冠心病相关性的病例-对照研究,检索时限均从建库至2018年3月。由2名研究者独立筛选文献、资料提取,使用Newcastle-Ottawa Scale(NOS)评价研究质量,并评价纳入研究的偏倚风险后,采用RevMan 5.3和Stata12.0进行Meta分析。结果:本研究共纳入8项病例对照研究(病例组1 675例,对照组1 735例)。Meta分析结果显示:Apo M基因rs805296多态性与冠心病的发生有关(C vs.T:OR=1.76,95%CI:1.50~2.06,P=0.00;CC+CT vs.TT:OR=1.85,95%CI:1.56~2.20,P=0.00;CC vs.CT+TT:OR=1.92,95%CI:1.08~3.40,P=0.03;TC vs.TT:OR=1.83,95%CI:1.53~2.19,P=0.00;CC vs.TT:OR=2.15,95%CI:1.21~3.81,P=0.009)。结论:Apo M基因rs805296多态性与冠心病有关,C等位基因是其潜在危险因素。

Objective： To investigate the relationship between rs805296 polymorphisms in ApoM gene and risk of coronary heart disease（ CHD） Methods： We searched Web of Science,EMbase,PubMed,The Cochrane Library,CNKI,VIP and Wan Fang Data databases to collect case-control studies on rs805296 polymorphisms of Apo M gene and risk of coronary heart disease from inception to February 2018. Two reviewers independently screened literature,extracted data,and assessed the risk of bias of included studies. The quality of included articles was evaluated according to recommendation of Newcastle-Ottawa Scale（ NOS）,and meta-analysis was then performed by Rev Man 5. 3 and Stata 12. 0 software. Results： A total of 8 studies were included（ cases： 1675,controls： 1735） The result of meta-analysis showed that rs805296 polymorphism in Apo M gene was associated with risk of coronary heart disease（ C vs. T： OR = 1. 76,95% CI： 1. 50-2. 06,P = 0. 00; CC ＋CT vs. TT： OR = 1. 85,95% CI： 1. 56-2. 20,P = 0. 00; CC vs. CT ＋ TT： OR = 1. 92,95% CI： 1. 08-3. 40,P =0. 03; TC vs. TT： OR = 1. 83,95% CI： 1. 53-2. 19,P = 0. 00; CC vs. TT： OR = 2. 15,95% CI： 1. 21-3. 81,P =0. 009） Conclusion： rs805296 polymorphisms in Apo M gene is associated with risk of coronary heart disease,in which the C allele of Apo M may be a risk factor.