强迫症未服药患者静息态脑镜像同伦功能连接的初步观察

A preliminary study of inter-hemispheric resting-state mirror functional homotopy in drug-naive patients with obsessive-compulsive disorder

目的 探讨静息状态下强迫症未服药患者脑镜像同伦功能连接的模式.方法 纳入符合DSM-Ⅳ-TR中强迫症诊断标准的20例强迫症未服药患者（患者组）,以及20名性别、年龄和受教育程度与之相匹配的健康对照者（对照组）.采用Y-BOCS、HAMD17、HAMA评估强迫思维、强迫行为以及抑郁、焦虑症状.所有被试者进行全脑静息态功能磁共振扫描,基于DPABI分析软件,采用基于体素的镜像同伦连接（voxel-mirrored homotopic connectivity,VMHC）方法分析强迫症患者静息态全脑镜像同伦功能连接模式;采用偏相关分析方法分析强迫症患者全脑VMHC值与临床症状之间的关系.结果 与对照组相比,患者组双侧眶额回VMHC值降低（0.76±0.23与0.39±0.13,t=-5.46,P＜0.01,高斯随机场理论校正）;患者组双侧背外侧前额叶VMHC值与其强迫思维呈负相关（r=-0.912,P＜0.01,Bonferroni校正）.结论 静息状态下强迫症未服药患者双侧眶额回镜像同伦功能连接降低,双侧背外侧前额叶之间镜像同伦功能连接改变可能与强迫思维相关.

Objective To explore the pattern of inter-hemispheric resting-state mirror functional homotopy in the drug-naive obsessive-compulsive disorder （OCD）.Methods Twenty patients with OCD meeting with the DSM-Ⅳ-TR criteria and 20 gender-,age-,education-matched healthy subjects participated in the resting-state brain functional magnetic resonance imaging scan.The Y-BOCS,HAMD17 and HAMA were used to assess clinical symptoms （i.e.obsessive,compulsive,depressive and anxiety symptoms）.Based on the data processing ＆ analysis for （resting-state） brain imaging （DPABI） software,a voxel-mirrored homotopic connectivity （VMHC） approach was used to explore the pattern of inter-hemispheric resting-state mirror functional homotopy in OCD;partial correlation analysis was used to analysis the relationship between the whole brain VMHC value and clinical symptoms in OCD.Results Compared with the controls,the OCD patients showed decreased VMHC values in the orbitofrontal cortex （0.76±0.23 vs.0.39±0.13,t=-5.46,P〈0.01,gaussian random field corrected,two-tailed）;the VMHC value of bilateral dorsolateral prefrontal cortex was negatively correlated with obsessive thought （r=--0.912,P〈0.01,Bonferroni correction）.Conclusions Reduced interhemispheric resting-state functional homotopy in the orbitofrontal cortex is observed in OCD patients,and the interhemispheric resting-state functional homotopy in the bilateral dorsolateral prefrontal cortex may be relate with obsessive thought of OCD patients.