绝经后骨质疏松症的治疗进展

Treatment progress of postmenopausal osteoporosis

骨质疏松症的发病机制是骨吸收和骨形成的失衡,绝经后骨质疏松症(PMOP)的发病率较高,易形成骨折,尤其是椎体骨折,影响患者的生活质量,严重时可致残。目前治疗骨质疏松症的方法是在强调改善生活方式、适量运动、纠正不良生活习惯的基础上予以抗骨质疏松药物治疗。治疗的终极目标是防止脆性骨折发生。药物治疗安全性较高,但也有一定的不良反应,临床医生在选择药物治疗时,要根据患者的自身情况进行安全评估,个体化选择用药。本文对PMOP的治疗方法予以综述。

The basic mechanism of osteoporosis is imbalances of bone resorption and bone formation. The incidence of osteoporosis is higher among postmenopausal women, and it is easy to form fracture, especially vertebral fracture. Osteoporosis will influence the patient＇s quality of life, resulting in disability when condition gets worst. The present method of treatment is to give anti-osteoporosis drugs on the basis of improving lifestyles, keeping physically activities, and correcting bad habits. The goal of treatment is to prevent the fragility fracture. The security of drug therapy is higher, but it has a certain adverse drug reactions. When clinicians choose drugs, it has to be comprehensively evaluated patients＇ self-conditions, and choose drugs individually for every patient. This article gives summarize of therapeutic method of postmenopausal osteoporosis.