伴有抑郁症状的轻度认知功能障碍患者脑功能局部一致性

The regional homogeneity of brain function in patients with mild cognitive impairment with depressive symptoms

目的:研究伴有抑郁症状的轻度认知功能障碍(MCI)患者脑功能局部一致性。方法:使用3.0T MR扫描仪对16例MCI伴随抑郁症状的患者(D-MCI组)和18例无抑郁症状的MCI患者(nD-MCI组)进行扫描,并获得静息状态下的功能磁共振成像(rs-f MRI)数据,评估2组间CReHo不同的区域,同时对CReHo指数与临床量表进行相关性分析,以此评价CReHo与MCI患者病理生理指标之间的相关性。结果:与nD-MCI组比较,D-MCI组患者左侧颞横回和右侧丘脑区的CRe Ho值显著增高,而左侧中央后回的CRe Ho值减低。左侧丘脑的CRe Ho值与D-MCI患者的汉密尔顿抑郁量表得分呈正相关。结论:感觉运动网络异常可能是伴有抑郁症状MCI的主要病理生理因素之一。

Objective： To investigate the local consistency of brain function in patients with mild cognitive impairment with depressive symptoms. Methods： We scanned 16 patients with MCI with depressive symptoms and 18 MCI patients without depressive symptoms （nD-MCI） using the 3.0T MR scanner and obtained rs-fMRI data. Statistical analysis was used to assess the different regions of CReHo between the two groups. And the cor-relation between CReHo index and clinical scale was analyzed to evaluate the correlation between CReHo and pathophysiological indicators. Results： The CReHo value of the left Heschl and right thalamus areas in the D-MCI group was significantly higher than that in the non-depressive group, while the CReHo value of the left posterior central gyrus was reduced. In addition, our study also showed that the CReHo value of the left thalamus was positively correlated with the Hamilton Depression Scale （HAMD） score of D-MCI patients. Conclusion： These fndings suggest that abnormal sensory motor network may be one of the main pathophysiological factors of D-MCI.