血小板蛋白酶活化受体-1水平对稳定型心绞痛患者长期预后的影响

Effect of platelet protease activated receptor 1 level on long-term prognosis of patients with stable angina pectoris

目的探讨血小板蛋白酶活化受体-1(PAR-1)水平对稳定型心绞痛(SAP)患者长期预后的影响。方法纳入125例SAP患者,收集患者的一般临床资料并检测入院时富血小板血浆中PAR-1的水平,记录随访18个月期间心血管事件的发生情况。采用受试者工作特征曲线分析PAR-1对SAP患者发生心血管事件的预测效能,分析SAP患者发生心血管事件的影响因素。结果 125例SAP患者PAR-1水平为(2. 79±0. 34) pg/ml。TC、LDL、心绞痛加拿大心血管协会分级、PAR-1水平均为SAP患者心血管事件发生的影响因素(均P <0. 05)。当PAR-1为2. 854 ng/ml时,其预测SAP患者发生心血管事件的敏感度、特异度分别为76. 1%、91. 4%。结论 PAR-1水平升高是SAP患者发生心血管事件的重要危险因素,其可作为评估SAP长期预后的指标。

Objective To investigate the effect of platelet protease activated receptor 1（PAR-1） level on the long-term prognosis of the patients with stable angina pectoris（SAP）. Methods A total of 125 patients with SAP were included.The general clinical data of the patients were collected,the PAR-1 expression of platelet-rich plasma was detected on admission,and the incidence of cardiovascular events during the 18-month follow-up was recorded.The efficiency of PAR-1 for predicting the occurrence of cardiovascular events in the SAP patients was analyzed using receiver operating characteristic curve.The factors influencing the incidence of cardiovascular events in the SAP patients was analyzed. Results The PAR-1 level of the 125 SAP patients was 2.79±0.34 pg/ml.TC,LDL,Canadian Cardiovascular Society classification,and PAR-1 level were the influencing factors of cardiovascular events（all P 〈0.05）.The sensitivity and specificity for predicting the occurrence of cardiovascular events in the SAP patients were 76% and 91.4% respectively. Conclusion Increased PAR-1 level is the important risk factor for the occurrence of cardiovascular events in the SAP patients,and it can act as an indicator for evaluating the long-term prognosis of SAP.