摘要
在氧化剂作用下,以廉价易得的氯乙酰作为氯的来源,选择性地实现了8-氨基喹啉酰胺类化合物的C-5位的氯化反应.该反应有很好的底物适应性和官能团兼容性.
The oxone promoted C-5 chlorination of 8-aminoquinoline amides under mild reaction conditions has been demonstrated.This reaction uses acetyl chloride which is cheap and easy to get as the chlorine source.Besides, the reaction has exhibited a broad substrate scope and high functional-group tolerance.
作者
李丹丹
蒋永帅
浮光宾
LI Dandan;JIANG Yongshuai;FU Guangbin(College of Chemistry and Chemical Engineering,Xuchang University,Xuchang 461000,China)
出处
《许昌学院学报》
CAS
2018年第10期39-42,共4页
Journal of Xuchang University
基金
河南省教育厅重点项目(17A150050)
关键词
8-氨基喹啉酰胺
氯化
C-Cl键的构建
8 - aminoquinoline amides
chlorination
construction of C - Cl bond
