屈螺酮炔雌醇与炔雌醇环丙孕酮治疗多囊卵巢综合征的疗效比较研究

Comparative effectiveness research of drospirenone ethinylestradiol and ethinylestradiol cyproterone in treating polycystic ovary syndrome

目的比较屈螺酮炔雌醇与炔雌醇环丙孕酮治疗多囊卵巢综合征的临床疗效。方法选取徐州医科大学附属徐州市立医院门诊2016年1月—2017年1月收治的多囊卵巢综合征患者86例,随机分为对照组和观察组,各43例。对照组患者采用炔雌醇环丙孕酮治疗,观察组患者采用屈螺酮炔雌醇治疗,两组患者均持续治疗3个周期。比较两组患者治疗前后促黄体生成激素(LH)、卵泡生成激素(FSH)、孕酮(P)及睾酮(T),观察两组患者药物不良反应发生情况。结果治疗前,两组患者LH、FSH、P及T比较,差异无统计学意义(P>0.05);治疗后,观察组患者LH、T低于对照组,FSH、P高于对照组(P<0.05)。观察组患者药物不良反应发生率低于对照组(P<0.05)。结论屈螺酮炔雌醇治疗多囊卵巢综合征的临床疗效优于炔雌醇环丙孕酮,其可更有效地减轻疾病对患者性激素代谢的损伤程度,提高药物治疗安全性和可靠性。

Objective To compare the clinical efficacy of drospirenone ethinylestradiol and ethinylestradiol cyproterone in treating polycystic ovary syndrome.Methods A total of 86 cases of polycystic ovary syndrome patients were selected from January 2016 and January 2017 in Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University,which were randomly divided into control group and observation group,43 cases in each group.The control group was treated with ethinylestradiol cyproterone,observation group was treated with drospirenone ethinylestradiol,both groups were treated for 3 cycles.The LH,FSH,P,T before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,no significant differences of LH,FSH,P or T was found between the two groups（P〉0.05）;after treatment,the LH,T in observation group were lower than control group,while FSH,P were higher than control group（P〈0.05）.The incidence rate of adverse reactions in observation group was lower than control group（P〈0.05）.Conclusion Drospirenone ethinylestradiol has a better clinical effect than ethinylestradiol cyproterone in treating polycystic ovary syndrome,which can more effectively reduce the damage of diseases to sex hormones of patients,and improve the safety and reliability of drug treatment.