腰硬联合麻醉对老年患者认知功能及趋化因子、黏附因子的表达影响研究

The affect research of combined spinal and epidural anesthesia on cognitive function, expression of chemokines and adhesion factors in elderly patients

目的分析腰硬联合麻醉对老年患者认知功能及趋化因子、黏附因子的表达影响。方法选取2014年1月～2015年9月于本院进行手术治疗的64例老年患者为研究对象,将其根据随机数字表法分为对照组(全麻组)32例和观察组(腰硬联合麻醉组)32例,然后将两组患者麻醉后12h、24h及48h的认知功能相关血清指标及趋化因子、黏附因子水平进行比较。结果麻醉后12h、24h及48h观察组的认知功能相关血清指标及趋化因子、黏附因子水平均低于对照组(P均<0.05)。结论腰硬联合麻醉对老年患者认知功能及趋化因子、黏附因子的表达影响更为积极,对于控制患者各方面不良情况均有积极的临床作用。

Objective To analyze the influence of combined spinal and epidural anesthesia on cognitive function, expression of chemokines and adhesion factors in elderly patients. Methods Sixty-four elderly patients who underwent surgery in our hospital from January 2014 to September 2015 were selected as subjects. According to the random number table method, 32 cases were divided into the control group（general anesthesia group） and 32 cases in the observation group（combined spinal and epidural anesthesia group）. The cognitive function-related serum indexes, chemokines and adhesion factors were compared at 12h, 24h and 48h after anesthesia between the two groups. Results At 12h, 24h and 48h after anesthesia, the cognitive function-related serum index, chemokine and adhesion factor levels in the observation group were lower than those in the control group（P 〈 0.05）. Conclusion Combined spinal and epidural anesthesia has a more positive effect on the cognitive function, chemokines and adhesion factors expression in elderly patients, and has a positive clinical effect on controlling all aspects of patients＇ adverse conditions.