替格瑞洛与氯吡格雷在急性冠脉综合征介入治疗患者中应用的对比研究

Comparative study of ticagrelor and clopidogrel in interventional therapy for acute coronary syndrome patients

目的探讨替格瑞洛与氯吡格雷在急性冠脉综合征介入治疗患者中应用价值。方法选择2016年10月～2018年1月本院收治的急性冠脉综合征实施介入治疗者76例,按照随机数字表法分为两组,各38例,观察组使用替格瑞洛片,对照组使用氯吡格雷片,比较室性早搏短阵室速发生率比例及评价纽约心功能变化,比较干预后心率变异性变化。结果观察组室性早搏短阵室速发生比例显著少于对照组(P <0.05),纽约心功能评级水平显著优于对照组(P <0.05),观察组全部窦性R-R间期标准差(SDNN)、每5分钟窦性R-R平均值标准差(SDANN)均高于对照组(P <0.05),观察组出现心力衰竭和心律失常比例低于对照组(P <0.05)。结论针对急性冠脉综合征,应用替格瑞洛,相对于使用氯吡格雷者,可显著减少心肌损伤,改善心功能,减少并发症,提高患者预后。

Objective To explore the clinical value of tieagrelor and elopidogrel in interventional therapy for acute coronary syndrome patients. Methods Seventy-six acute coronary syndrome patients with interventional therapy in our hospital from October 2016 to January 2018 were selected,they were divided into two groups by random number method,each had 38 eases.The observation group was used tieagrelor,the control group was used elopidogrel,eompared the incidence ratio of premature ventrieular contractions nonsustained ventrieular taehyeardia,eompared the changes in New York heart association,and the changes in heart rate variability after intervention. Results The incidence of premature ventrieular contractions nonsustained ventrieular taehyeardia in the observation group was significantly lower than that in the control group （P 〈 0.05）.The level of New York heart association in the observation group was signifieantly better than the eontrol group （P 〈 0.05）,Total sinus R-R interval standard deviation （SDNN） and sinus R-R average standard deviation for each 5rain （SDANN） of the observation were both higher than those of the control group （P 〈 0.05）,the incidence of heart failure and arrhythmia in the observation group was lower than that in the control group（P 〈 0.05）. Conclusion For acute coronalT syndrome,compare with clopidogrel,tieagrelor can significantly reduce myocardial damage,improve cardiac function,reduce complications,improve patient outcomes.