血糖变异性对脑出血并发2型糖尿病患者抑郁的影响

Effect of blood glucose variability on depression in patients with cerebral hemorrhage complicated with type 2 diabetes

目的探讨血糖变异性对脑出血并发糖尿病患者抑郁的影响。方法选取2014年6月～2016年12月期间收治的90例2型糖尿病并发脑出血患者,根据是否患有抑郁分为抑郁组和非抑郁组,比较两组患者的临床资料、评价不同血糖变异水平与抑郁发生的关系。结果两组患者在性别构成比、年龄、BMI、饮酒史、吸烟史、既往病史比较差异无统计学意义(P> 0.05);抑郁组患者在病程、入院时NIHSS评分、MAGE、GV方面比较显著高于非抑郁组患者,差异比较有统计学意义(P <0.05);Spearman相关分析结果进一步表明,GV水平与脑出血后3个月抑郁发生呈正相关(r=0.512,P <0.05)。结论血糖变异性能够增加2型糖尿病患者脑出血后3个月抑郁的风险,提示降低血糖波动可能是减少脑出血患者抑郁的一项有效措施,更有利于改善预后。

Objective To explore the effect of blood glucose variability on depression in patients with cerebral hemorrhage complicated with type 2 diabetes. Methods 90 patients with type 2 diabetes complicated with cerebral hemorrhage from June 2014 to December 2016 were selected, and divided into depression group and non-depressive group according to whether depression, the clinical data of the two groups were compared, and the relationship between the different blood glucose variation levels and the occurrence of depression was evaluated. Results There were no significant differences in gender composition ratio, age, BMI, drinking history, smoking history, and past medical history between the two groups （P〉 0.05）.Patients in the depression group had significantly higher NIHSS scores, MAGE, and GV at admission than those in the non-depressed group, the difference was statistically significant （P 〈 0.05）.Spearman correlation analysis showed that GV levels were positively correlated with depression at 3 months afler cerebral hemorrhage （r=0.512, P 〈 0.05）. Conclusion Blood glucose variability can increase the risk of depression in 3 months afler cerebral hemorrhage in patients with type 2 diabetes. It prompts to reduce blood sugar fluctuations may be an effective measure to reduce depression in patients with cerebral hemorrhage, and is more conducive to improving prognosis.