沙美特罗替卡松治疗支气管扩张合并不可逆气流受限的疗效分析

Efficacy analysis of salmeterol fluticasone in treatment of bronchiectasis with irreversible airflow limitation

目的观察沙美特罗替卡松治疗支气管扩张合并不可逆气流受限的临床效果。方法将支气管扩张合并不可逆气流受限患者100例随机分为观察组和对照组各50例,对照组采用常规祛痰、抗感染方案治疗,观察组在对照组基础上采用沙美特罗替卡松治疗。对比观察2组肺功能指标、呼吸困难评分及炎性指标改善情况。结果治疗后对照组PEF、FEV1/FVC、FEV1变化不明显,差异无统计学意义(P> 0.05),但观察组PEF、FEV1/FVC、FEV1明显升高,与治疗前与对照组比较差异有统计学意义(P <0.05)。治疗后2组呼吸困难评分均降低,且观察组降低幅度更大,差异有统计学意义(P <0.05)。治疗后2组TNF-α、IL-6水平均改善,且观察组改善程度优于对照组,差异有统计学意义(P <0.05)。结论沙美特罗替卡松治疗支气管扩张合并不可逆气流受限可有效增强肺功能,促进康复进程。

Objective To investigate the clinical effects of salmeterol fluticasone therapy in patients with bronchiectasis and irreversible airflow limitation.Methods 100 patients with bronchiectasis and irreversible airflow limitation were randomly divided into observation group and control group,each of 50 cases.Control group was treated with conventional sputum and anti-infective regimen,and observation group was treated with salmeterol fluticasone on the basis of control group.The lung function indexes,dyspnea scores and improvement indexes of two groups were compared.Results After treatment,the changes of PEF,FEV1/FVC and FEV1 in control group were not obvious,and the difference was not statistically significant（P〉0.05）,but the PEF,FEV1/FVC and FEV1 in observation group were significantly increased,compared with before treatment and control group the difference was statistically significant（P〈0.05）.After treatment,the scores of dyspnea in both groups were decreased,and the reduction in observation group was greater,and the difference was statistically significant（P〈0.05）.After treatment,the levels of TNF-α and IL-6 were improved in two groups,and the improvement of observation group was better than that of control group,the difference was statistically significant（P〈0.05）.Conclusion The patients with bronchiectasis with irreversible airflow limitation can effectively enhance the lung function and promote the process of rehabilitation by using salmeterol fluticasone therapy.