枸橼酸咖啡因治疗早产儿原发性呼吸暂停的疗效观察

Observation of curative effect of caffeine citrate in treatment of primary apnea in preterm infants

目的观察枸橼酸咖啡因治疗早产儿原发性呼吸暂停的临床疗效。方法将原发性呼吸暂停早产儿69例,根据治疗方式不同分为观察组33例和对照组36例,观察组给予枸橼酸咖啡因注射液治疗,对照组给予氨茶碱治疗。对比2组临床疗效及不良反应发生情况。结果观察组用药后3 d、7 d时的有效率均高于对照组,差异均有统计学意义(P <0.05)。观察组不良反应发生率显著低于对照组,差异有统计学意义(P <0.05)。结论枸橼酸咖啡因治疗早产儿原发性呼吸暂停效果优于氨茶碱,安全有效,不良反应少,临床应用价值较高。

Objective To explore the efficacy of caffeine citrate in treatment of primary apnea in preterm infants.Methods According to different treatment methods,69 cases of primary apnea premature infants were divided into observation group 33 cases and control group 36 cases.Observation group was treated with citrate caffeine injection and control group was treated with aminophylline.The clinical efficacy and adverse reactions of two groups were compared.Results The effective rate of observation group at 3 and 7 days after treatment was higher than that of control group,and the difference was statistically significant（P〈0.05）.The incidence of adverse reactions in observation group was significantly lower than that in control group,and the difference was statistically significant（P〈0.05）.Conclusion The effect of caffeine citrate on primary apnea in premature infants is better than aminophylline,safe and effective,low adverse reaction and high clinical value.