丹参川芎嗪联合电针刺激等治疗颈源性高血压临床效果观察

The Clinical Effect of Salvia Miltiorrhiza Ligustrazine Combined with Electric Acupuncture in Patients with Cervical Hypertension

目的观察丹参川芎嗪联合电针刺激等治疗颈源性高血压的临床效果。方法选择符合纳入及排除标准的颈源性高血压100例,按入组先后顺序将其分为观察组与对照组两组各50例,其中观察组36例和对照组38例顺利完成临床研究且能提供可靠临床试验数据。观察组采用丹参川芎嗪联合电针刺激等治疗,对照组采用电针刺激等治疗,均连续治疗2周。观察比较两组动脉血流动力学指标及血液流变学指标、血压情况、疼痛情况、临床疗效。结果治疗后,两组动脉平均血流速度(Vm)均高于治疗前,动脉阻力指数(RI)及搏动指数(PI)均低于治疗前;观察组动脉Vm均高于对照组,动脉RI和PI均低于对照组,差异有统计学意义(P <0. 05)。治疗后两组血液流变学指标、血压及视觉模拟评分法(VAS)评分均低于治疗前,观察组血液流变学指标、血压及VAS评分均低于对照组,差异有统计学意义(P <0. 05)。治疗后观察组总有效率高于对照组,差异有统计学意义(P <0. 05)。结论丹参川芎嗪联合电针刺激等治疗颈源性高血压可改善患者动脉血流动力学及血液流变学指标,能达到降低血压及缓解疼痛的目的,且临床效果良好。

Objective To research the effect of electric acupuncture combined with salvia miltiorrhiza ligustrazine on patients with cervical hypertension. Methods One hundred patients with cervical hypertension who met inclusion and exclusion criteria were enrolled and randomly divided into observation group （ n =50） and control group （ n =50） according to the order of enrollment. Of them, 36 cases in observation group and 38 in control group successfully completed clinical research and provided reliable clinical and experimental data. The patients in the control group were given electric acupuncture, and those in the observation group were given salvia miltiorrhiza ligustrazine on the basic of control group. The course of treatment was 2 weeks. The arterial hemodynamic parameters, hemorheology, blood pressure （BP）, pain and clinical efficacy were compared between the two groups. Results After treatment, the mean blood flow velocity （Vm） of the two groups was higher than that before treatment, while the arterial resistance index （RI） and pulsatility index （PI） were lower than those before treatment. The arterial Vm of the observation group was higher while both arterial RI and PI were lower, as compared with control group, and there were significant differences （ P 〈0.05）. After treatment, the hemorheology index, BP and visual analog scale （VAS） scores of the two groups were lower than those before treatment. The blood rheology index, BP and VAS scores of the observation group were lower than those in the control group, and significant difference was found （ P 〈0.05）. After treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant （ P 〈0.05）. Conclusion Salvia miltiorrhiza ligustrazine combined with electric acupuncture can lower BP and relieve the pain by improving artery hemodynamics and hemorheology of patients with cervical hypertension. Therefore, it has good therapeutic effect.