CysC与RBP联合检测对脑动脉瘤早期诊断的应用探讨

The clinical significance of the combined detection of CysC and RBP for Early diagnosis of CA

目的探讨血清胱抑素C(Cystain C,CysC)与视黄醇结合蛋白(retinol binding protein,RBP)和脑动脉瘤(Cerebral aneurysm,CA)的相关性,以及两者联合检测在CA早期诊断的临床应用价值。方法选择108例经头颅CTA(CT血管造影)或MRA(磁共振血管成像)或DSA(数字减影血管造影)确诊为CA患者为观察组,90例同期体检健康者为对照组,均进行CysC和RBP浓度测定,进行统计学分析。并对观察组和对照组临床资料进行分析。结果CA患者CysC和RBP水平均明显高于健康体检者(t=12.11,9.57 P<0.01)。与单独检测比较,差异均有统计意义(χ2=20.41,10.78 P<0.05)。考虑性别、吸烟是CA发生的危险因素。结论 CysC和RBP浓度在CA中明显升高;联合检测CysC与RBP灵敏度和特异度相对较好,对CA的早期诊断具有重要的临床价值,能有效地提高阴性检出率;女性,具有吸烟史均是CA发生的危险因素。

Objective To investigate the correlation between serum cystatin C（CysC）and retinol binding protein（RBP）and cerebral aneurysm（CA）,and their clinical significance in the early diagnosis of CA.Methods 108 patients with CA diagnosed by head CTA（CT angiography）or MRA（magnetic resonance angiography）or DSA（digital subtraction angiography）were selected as the observation group,and 90 healthy subjects in the physical examination department of the same period were the control group.CysC and RBP concentrations were measured and statistically analyzed.The clinical data of the observation group and the control group were analyzed.Results The levels of CysC and RBP in CA patients were significantly higher than those in healthy subjects（t=12.11,9.57 P〈0.01）.Compared with the single test,the differences were statistically significant（χ^2= 20.41,10.78 P〈0.05）.Conclusion Sex and smoking are risk factors for the occurrence of CA.Conclution CysC and RBP for the early diagnosis of CA has important clinical value,combined detection of CysC and RBP can effectively increase the positive detection rate and reduce the rate of missed diagnosis.