2型糖尿病并发胆囊结石的危险因素分析

Analysis on the risk factors of gallstones in patients with type 2 diabetes mellitus

目的 探讨2型糖尿病（T2DM）患者并发胆囊结石的危险因素.方法 选取2017年2月至2018年1月在胶州市第二人民医院内分泌科住院治疗的T2DM患者952例,根据是否患有胆囊结石,将其分为胆囊结石组（n=118）与非胆囊结石组（n=834）.采用单因素分析与多因素Logistic回归分析患者并发囊结石的危险因素.结果 两组患者血Ca、三酰甘油（TG）水平及糖尿病下肢动脉病变（LEAD）情况比较差异有统计学意义（P〈0.05）.多因素Logistics回归分析表明,TG（OR=1.089,95％CI：1.025～1.157,P=0.008）与LEAD（OR=2.215,95％CI：1.321～3.716,P=0.004）是T2DM患者并发胆囊结石的危险因素.结论 高TG血症患者与合并LEAD的T2DM患者发生胆囊结石的风险较高,临床治疗中应当采取积极措施纠正患者脂代谢异常以预防胆囊结石症发生.

Objective To evaluate the risk factors of gallstones in patients with type 2 diabetes mellitus （ T2DM ）. Methods Nine hundred and fifty-two patients with T2DM hospitalized in Endocrinology Department of the Second People ＇s Hospital of Jiaozhou from February 2017 to January 2018 were selected .According to whether has gallstones or not , the patients were divided into gallstone group （118 cases） and non-gallstone group （834 cases）.Univariate analysis and multivariate Logistic regression analysis were used to analyze the risk factors of gallstones .Results There were statistically significant differences in level of blood Calcium （Ca）, triglyceride （TG） and diabetic lower extremity atherosclerotic disease （LEAD） between the two groups （P〈0.05）.Multivariate logistic regression analysis showed that TG （OR=1.089, 95%CI：1.025-1.157, P=0.008） and LEAD （OR=2.215, 95%CI：1.321-3.716, P=0.004） were risk factors of gallstone development in patients with T 2DM.Conclusions The risk of gallstone is higher in patients with high TG and LEAD patients complicated by T 2DM.Active measures should be taken to correct abnormal lipid metabolism in clinical so as to prevent gallstones .