阿司匹林与氯吡格雷联合治疗急性脑梗死的疗效研究

Efficacy research of Aspirin combined with Clopidogrel in the treatment of acute cerebral infarction

目的研究阿司匹林与氯吡格雷联合治疗急性脑梗死的疗效。方法 75例急性脑梗死患者,随机分为对照组(35例)和观察组(40例)。在常规护理和治疗方法基础上,对照组患者采取阿司匹林肠溶片进行治疗,观察组患者采取阿司匹林肠溶片联合氯吡格雷片进行治疗,比较两组患者的临床疗效。结果观察组治疗总有效率为97.50%,明显高于对照组的82.86%,差异有统计学意义(P<0.05)。治疗前,两组患者神经功能评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者神经功能评分低于对照组,差异具有统计学意义(P<0.05)。结论使用阿司匹林肠溶片联合氯吡格雷片治疗急性脑梗死患者,其治疗效果以及对患者的神经功能改善效果明显优于单纯使用阿司匹林肠溶片治疗,值得临床推广。

Objective To research the efficacy of Aspirin combined with Clopidogrel in the treatment of acute cerebral infarction. Methods A total of 75 patients with acute cerebral infarction were randomly divided into control group for 35 cases and observation group for 40 cases. On the basis of conventional nursing and treatment methods, patients in the control group were treated with Aspirin Enteric-coated Tablets, patients in the observation group were treated with Aspirin Enteric-coated Tablets combined with Clopidogrel Tablets. The clinical effects of the two groups were compared. Results The total effective rate of the observation group was 97.50%, which was significantly higher than 82.86% of the control group, the difference was statistically significant（P〈0.05）. Before treatment, there was no significant difference in the neurological function score between the two groups（P〉0.05）. After treatment, the neurological function score of the observation group was significantly lower than that of the control group, the difference was statistically significant（P〈0.05）. Conclusion The application of Aspirin Enteric-coated Tablets combined with Clopidogrel Tablets on the therapeutic effect and the improvement of neurological function in the treatment of acute cerebral infarction patients is superior to the simple use of Aspirin Enteric-coated Tablets treatment, it is worthy of clinical promotion.