功能性消化不良的中医用药规律及证素分布文献研究

Document research on the pharmacological regularity and syndrome distribution of functional dyspepsia in traditional Chinese medicine

目的探索功能性消化不良的中医临床用药规律及其证素分布,为临床治疗提供帮助。方法以中国学术期刊全文数据库(CNKI)为文献来源,统计2007年1月—2016年12月间符合要求的治疗功能性消化不良的方剂,运用SPSS Statistics 20. 0和SPSS Modeler 15. 0分析其用药规律及证素分布。结果治疗功能性消化不良的常用药为甘草、白术、茯苓、柴胡、半夏、陈皮、枳壳、党参、白芍、厚朴。治疗功能性消化不良的常用药物种类为理气药、补气药、消食药、化湿药、清热药。功能性消化不良的主要病位在胃、脾,同时涉及肝,主要的病性证素为气滞、气虚、热、阳虚、血瘀。常用的药对是柴胡和川芎、柴胡和郁金、白术和莱菔子、白术和枳实、白术和麦芽,常用的角药为柴胡—白芍和枳壳、白术—麦芽和六神曲、白术—麦芽和茯苓、白术—山楂和陈皮、柴胡—香附和白芍。治疗功能性消化不良的基本方为党参、茯苓、白术、甘草、枳壳、白芍、柴胡、陈皮、厚朴、半夏。结论功能性消化不良病位主要在胃、脾,同时与肝相关,病性多为气滞、气虚和热,夹有阳虚和血瘀,用药以理气、补气为主,导滞清热化湿为辅,其基本方为党参、茯苓、白术、甘草、枳壳、白芍、柴胡、陈皮、厚朴、半夏。

Objective To explore the medication rule of TCM and distribution of syndrome element for functional dyspepsia,to conducive clinical therapy. Methods Collecting satisfactory prescription which treat functional dyspepsia from January 2007 to December 2016 from China National Knowledge Internet（ CNKI）,and analyzing the medication rule and distribution of syndrome element. Results The common herbs to treat functional dyspepsia are Gancao,Baizhu,Fuling,Chaihu,Banxia,Chenpi,Zhiqiao,Dangshen,Baishao,Houpo. The types of commonly used herbs are qi-regulating herbs,qitonifying herbs,digestant herbs,dampness-resolving herbs,heat-clearing herbs. The main disease location of functional dyspepsia is stomach and spleen,at the same time involving liver. The main syndromes of nature of disease are stagnation of qi,deficiency of qi,heat,deficiency of yang,stagnation of blood. The common herb pairs are Chaihu and Chuanxiong,Chaihu and Yujin,Baizhu and Laifuzi,Baizhu and Zhishi,Baizhu and Maiya,the common triple herb combinations are Chaihu-Baishao and Zhiqiao, Baishao-Maiya and Liushenqu, Baizhu-Maiya and Fuling, Baizhu-Shanzha and Chenpi,Chaihu-Xiangfu and Baishao. The basic formula to treat functional dyspepsia is Dangshen,Fuling,Baizhu,Gancao,Zhiqiao,Baishao,Chaihu,Chenpi,Houpo,Banxia. Conclusion The main disease location of functional dyspepsia is stomach and spleen,at the same time involving liver,the main characters are stagnation of qi,deficiency of qi and heat,with some deficiency of yang and stagnation of blood,the main treatment is regulating the flow of qi and tonifying qi,removing stagnancy and clearing heat,resolving dampness as supplementary. The basic formula to treat functional dyspepsia is Dangshen,Fuling,Baizhu,Gancao,Zhiqiao,Baishao,Chaihu,Chenpi,Houpo,Banxia.