阿加曲班和依达拉奉联合治疗急性脑梗死临床研究

Clinical study on the treatment of acute cerebral infarction by argatroban and edaravone combined

目的:探讨急性脑梗死患者采用阿加曲班联合依达拉奉进行治疗的临床效果。方法:82例急性脑梗死患者,随机数表法分为对照组和观察组,各41例。常规对症治疗基础上,对照组给予依达拉奉治疗,观察组在对照组基础上联合阿加曲班治疗,对比两组患者的治疗总有效率,治疗前后神经功能缺损评分(NISS评分),治疗2周后采用Barthel评估患者的日常活动能力。结果:观察组治疗总有效率为95. 12%高于对照组的75. 61%(P <0. 05),观察组治疗2周后NISS评分较对照组降低,Barthel指数评分高于对照组(P <0. 05)。结论:与单独依达拉奉治疗比较,阿加曲班联合依达拉奉治疗急性脑梗死能有效减轻患者症状,改善神经功能和生活自理能力显著,值得临床推广应用。

Objective： To analyze the clinical effect of the treatment of acute cerebral infarction with the combination of argatroban and edaravone. Methods： 82 patients with acute cerebral infarction were randomly divided into control group and observation group,41 cases in each group.On the basis of routine symptomatic treatment,the control group was treated with edaravone,and the observation group was treated with argatroban on the basis of the control group.The total effective rate was compared between the two groups.The neurological deficit score （NISS score） before and after treatment was compared between the two groups.After 2 weeks of treatment,Barthel was used to assess the activities of daily living of patients. Results： The total effective rate of the observation group was 95.12%,which was higher than that of the control group （75.61%） （ P 〈0.05）.The NISS score of the observation group was significantly lower than that of the control group after 2 weeks of treatment,and the Barthel index score was higher than that of the control group （ P 〈0.05）. Conclusion： Compared with edaravone alone,argatroban combined with edaravone in the treatment of acute cerebral infarction can effectively alleviate symptoms,improve neurological function and self-care ability,which is worthy of clinical application.