柴胡疏肝散治疗抑郁症疗效的Meta分析

Meta-analysis of the Efficacy of Chaihu Shugan Powder in the Treatment of Depression

目的评价柴胡疏肝散治疗原发性抑郁症的有效性及安全性。方法系统检索Embase、Pubmed、Cochrane、CNKI、Wanfang、VIP、CHKD等数据库的RCT论文,采用Revman5.3软件进行Meta分析。结果纳入10项中国单中心研究共693例受试者。Meta分析显示:柴胡疏肝散治疗组在临床总有效率、汉密尔顿抑郁评分降低等方面均优于对照组(P<0.05),不良反应较少,安全性风险低。结论柴胡疏肝散治疗原发性抑郁症疗效良好。

Objective To evaluate the efficacy and safety of Chaihu Shugan Powder in the treatment of primary depression.Methods The RCT papers of Embase, Pubmed, Cochrane, CNKI, Wanfang, VIP, CHKD and other databases were systematically searched, and Meta-analysis was performed using Revman5.3 software. Results A total of 693 subjects from 10 Chinese single-center studies were included. Meta-analysis showed that the Chaihu Shugan Powder treatment group was superior to the control group in terms of total clinical effective rate and The reduction of Hamilton＇s depression score was better than that of the control group （P〈0.05）, with fewer adverse reactions and lower safety risks. Conclusion Chaihu Shugan Powder has a good effect in the treatment of primary depression.