鸦胆子油乳注射液辅助治疗大肠癌的Meta分析

Meta-analysis of Brucea Javanica Oil Emulsion Injection in the Treatment of Large Intestine Cancer

目的研究鸦胆子油乳注射液对大肠癌的辅助治疗作用。方法计算机检索PubMed、CNKI、WanFangData和VIP数据库中关于鸦胆子油乳注射液辅助治疗大肠癌的随机对照实验,检索时间截至2018年4月。评价纳入研究的偏倚风险后,采用RevMan5.3软件进行Meta分析。结果共纳入12个病例-对照研究,包括717例患者。鸦胆子油乳注射剂辅助治疗大肠癌患者的生活质量、临床疗效较对照组提高,不良反应低于对照组,差异有统计学意义(P<0.05)。结论本研究结果稳定性问题较理想,明确了鸦胆子油乳注射液在大肠癌治疗方面具有良好的辅助作用。

Objective To study the adjuvant therapeutic effect of Brucea javanica oil emulsion injection on large intestinecancer.Methods The randomized controlled trial on the adjuvant treatment of large intestinecancer with Brucea javanica oil emulsion injection was searched in PubMed,CNKI,WanFangData and VIP databases.The retrieval time was up to April 2018.After the bias risk was evaluated, Meta-analysis was performed with RevMan5.3 software.Results A total of 12 case-control studies were conducted, including 717 patients.The quality of life of patients with large intestinecancer treated with Brucea javanica oil emulsion injection was higher than that of the control group, and the adverse reaction was lower than that of the control group,differences between groups were statistically significant （P〈0.05）.Conclusion The stability of this study is satisfactory and it is clear that Brucea javanica oil emulsion injection has a good auxiliary effect in the treatment of large intestinecancer.