基于“交通心肾”理论研究天王补心丸对心肾综合征患者心肾功能及B型利钠肽变化的影响

Study on the Effect of Tianwang Buxin Pill on Cardiorenal Function and BNP Changes in Patients with Cardio-renal Syndrome Based on the Theory of“Traffic Heart and Kidney”

目的:观察天王补心丹对心肾综合征患者心肾功能的影响,同时探讨其对BNP浓度的干预效应。方法:选取2014年1月至2015年12月河南中医药大学第一附属医院收治的心肾综合征患者60例,按入院先后顺序随机分为对照组和观察组,每组30例。2组患者均接受肾内科常规药物治疗,观察组在常规治疗基础上加用天王补心丸,均以4周为1个疗程,疗程结束后比较2组临床总有效率、中医证候积分、心脏功能指标以及肾功能指标。结果:治疗后观察组临床总有效率明显高于对照组,且中医证候积分亦低于对照组,2组比较差异均有统计学意义(均P <0. 05)。2组治疗后24 h Upro、Uβ2-MG、SCr、BUN及UAER均较治疗前改善(均P <0. 05),观察组改善更明显(P <0. 05)。观察组治疗后心功能较对照组改善明显(P <0. 05)。2组治疗后BNP浓度均下降(均P <0. 05),观察组下降更明显(P <0. 05)。结论:天王补心丸可明显改善心肾综合征患者心肾功能,BNP浓度变化可有效判定疗效。

Objective To observe the effect of Tianwang Buxin Pill on heart and kidney function in patients with cardio-renal syndrome, and to explore its intervention effect on BNP concentration. Methods： Sixty patients with cardio-renal syndrome admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2014 to December 2015 were randomly divided into control group and observation group according to the order of admission, 30 cases in each group. The patients in both groups were treated with conventional drug treatment in the Department of Nephrology. The observation group was treated with Tianwang Buxin Pill on the basis of routine treatment. The two groups were treated with 4 weeks as a course of treatment. After the treatment, the change of two groups were compared in terms of the total effective rate, TCM syndrome score, cardiac function indicators and renal function indicators. Results： 1） After treatment, the total effective rate of the observation group was significantly higher than that of the control group, and the score of TCM syndrome was also lower than that of the control group. The difference of the two indexes was statistically significant （ P 〈0.05）. 2） The renal function indexes of the two groups after treatment： 24 h Upro, Uβ2-MG, SCr, BUN and UAER were better than before treatment, and the observation group improved more significantly （ P 〈0.05）. 3） After 4 weeks of treatment, the cardiac function of the observation group was significantly improved compared with the control group （ P 〈0.05）. 4） The concentration of BNP in the two groups decreased significantly after treatment, and the observation group decreased more significantly （ P 〈0.05）. Conclusion： Tianwang Buxin Pill can significantly improve the heart and kidney function of patients with cardio-renal syndrome. The change of BNP concentration can effectively evaluate the curative effect.