温阳活血汤对稳定期慢性阻塞性肺疾病脾肾阳虚证患者炎性反应因子的影响

Effects of Wenyang Huoxue Decoction on Inflammatory Factor in Patients with Stable Chronic Obstructive Pulmonary Disease with Syndrome of Yang Deficiency of Spleen and Kidney

目的:探讨温阳活血汤对稳定期慢性阻塞性肺疾病(COPD)脾肾阳虚证患者炎性反应因子的影响。方法:选取2016年1月至2017年1月青海省人民医院收治COPD患者158例作为研究对象,按照随机数表法随机分为观察组和对照组,每组79例。2组均给予布地奈德福莫特罗粉吸入剂治疗,观察组在此基础上给予温阳活血汤治疗。观察2组基线期及治疗后(治疗后2个月)肺功能参数及各项炎性反应因子变化。结果:基线期2组肺功能参数及各项炎性反应因子基本相同,差异无统计学意义(P> 0. 05);治疗后,观察组PEFR、FEV_1、FEV_1/FVC显著高于对照组,差异有统计学意义(P <0. 05),观察组血清IL-6、IL-8、TNF-α水平显著低于对照组,差异有统计学意义(P <0. 05)。结论:布地奈德福莫特罗粉吸入剂联合温阳活血汤治疗稳定期COPD脾肾阳虚证具有较好的疗效,其机制可能是通过降低患者血清IL-6、IL-8、TNF-α水平而达到治疗作用。

Objective To discuss the effects of Wenyang Huoxue Decoction on inflammatory factor in patients with stable chronic obstructive pulmonary disease （COPD） with syndrome of yang deficiency of spleen and kidney. Methods： A total of 158 patients with COPD were selected from January 2016 to January 2017 in Qinghai Provincial People′s Hospital,and were divided into observation group and control group according to the random number table method,with 79 cases in each group.Patients in the two groups were both given symbicort turbuhaler for treatment,and Wenyang Huoxue Decoction was added in the observation group.Changes in scores of revised pulmonary function parameters and inflammatory factor in every group were observed in baseline phase and after treatment （2 months after treatment）. Results： In baseline phase,pulmonary function parameters and inflammatory factor of two groups were basically the same,and there was no statistically significant difference （ P 〉0.05）.After treatment,PEFR,FEV 1 and FEV 1/FVC in the observation group were higher than those of the control group,which were statistically significant （ P 〈0.05）.IL-6,IL-8 and TNF-α in the observation group were lower than those of the control group,which were statistically significant （ P 〈0.05）. Conclusion： Symbicort turbuhaler combined with Wenyang Huoxue Decoction has good effects on treating stable chronic obstructive pulmonary disease with syndrome of yang deficiency of spleen and kidney.Mechanism may be associated with reducing patients′ serum levels of IL-6,IL-8 and TNF-α.