消瘤汤联合腹腔热灌注化疗对结直肠癌患者术后生命质量及血清血管内皮生长因子表达的影响

Effects of Xiaoliu Decoction Combined with Intraperitoneal Fever Chemotherapy on Postoperative Quality of Life and Serum VGEF Protein Expression in Patients with Colorectal Cancer

目的:探讨消瘤汤联合腹腔热灌注化疗对结直肠癌患者术后生命质量及血清血管内皮生长因子(VGEF)表达的影响,并探究其预防或抑制结直肠癌术后及转移的作用机制。方法:选取2011年7月至2013年10月唐山市丰润区人民医院收治的结直肠癌手术治疗患者82例,根据随机数字表法将所有患者随机分为对照组和观察组,每组41例。对照组术中及术后给予腹腔热灌注治疗,观察组在对照组基础上于患者排气排便后增加消瘤汤治疗。比较2组患者近远期临床疗效、术后生命质量及治疗前后VEGF水平和VEGF蛋白表达情况。结果:2组治疗后近期临床疗效差异无统计学意义(P> 0. 05),观察组3年内复发和转移率明显低于对照组(P <0. 05);治疗后2组功能领域评分均明显升高,且观察组明显高于对照组(P <0. 05),症状领域评分均明显降低,且观察组明显低于对照组(P <0. 05);治疗后2组VEGF水平及VEGF蛋白表达均明显降低(P <0. 05),且观察组明显低于对照组(P <0. 05)。结论:消瘤汤联合腹腔热灌注化疗可有效下调VEGF水平及VEGF蛋白表达,降低结直肠癌患者术后复发及率,提升患者术后生命质量。

Objective To investigate the effects of Xiaoliu decoction combined with intraperitoneal hyperthermic perfusion chemotherapy on postoperative quality of life and serum vascular endothelial growth factor （VGEF） protein expression in patients with colorectal cancer, and to explore its mechanism of preventing or inhibiting postoperative recurrence and metastasis of colorectal cancer. Methods： A total of 82 patients underwent surgical treatment of colorectal cancer in our hospital from July 2011 to October 2013 were selected and randomly divided into control group and observation group according to the computer generated digital table, with 41 cases in each groups.The control group was treated with intraperitoneal hyperthermic perfusion chemotherapy, and after the patient with defecation, the observation group on the basis of the control group received Xiaoliu decoction treatment.The clinical efficacy, postoperative quality of life and the expression of VEGF and VEGF protein were compared between the 2 groups before and after treatment. Results： There was no significant difference in clinical efficacy between the 2 groups after treatment （ P 〉0.05）, and the recurrence and metastasis rate of the observation group was significantly lower than those of the control group within 3 years （ P 〈0.05）.After treatment, the functional scores of the 2 groups significantly increased, and the observation group was significantly higher than the control group （ P 〈0.01）; symptomatic scores significantly decreased, and the observation group was significantly lower than the control group （ P 〈0.01）; after treatment, the expression of VEGF and VEGF protein in the 2 groups were significantly lower （ P 〈0.01）, and the observation group was significantly lower than the control group （ P 〈0.01）. Conclusion： Xiaoliu decoction combined with intraperitoneal hyperthermic perfusion chemotherapy can effectively down-regulate the expression of VEGF and VEGF protein, reduce the recurrence and metastasis rate of colorectal cancer patients, and improve the quality of life.