加味升阳益胃汤治疗腹泻型肠易激综合征的临床观察

Clinical Observation on Modified Shengyang Yiwei Decoction in the Treatment of Diarrhea Irritable Bowel Syndrome

目的观察加味升阳益胃汤治疗腹泻型肠易激综合征的临床疗效。方法采用随机数字表法,将60例腹泻型肠易激综合征患者分为治疗组、对照组,分别给予加味升阳益胃汤、马来酸曲美布汀片治疗,2组治疗疗程均为2周,观察2组患者治疗前后临床症状、不良反应、血清5-羟色胺(5-HT)等方面的变化及疗程结束后3个月回访时患者的症状、体征,比较2组患者的治疗效果。结果治疗组患者总有效率为93.3%(28/30),高于对照组患者总有效率83.3%(25/30)(P<0.05);在降低血清5-HT含量方面,治疗组明显优于对照组;治疗组不良反应发生2例,对照组不良反应发生3例,组间不良反应发生率无明显差异(P>0.05);治疗结束3个月后随访,治疗组患者复发率低于对照组(P<0.05)。结论加味升阳益胃汤对腹泻型肠易激综合征患者疗效确切,能明显降低远期复发率,且安全无明显毒副作用,有很高的临床价值,值得借鉴推广。

Objective To observe the clinical effect of modified Shengyang Yiwei decoction in the treatment of diarrhea irritable bowelsyndrome. Methods Using random number table method, 60 cases of diarrhea irritable bowel syndrome patients were divided intotreatment group and control group, and they were given modified Shengyang Yiwei decoction and maleic acid trimebutine treatmentrespectively for 2 weeks. Before and after treatment, clinical symptoms, adverse reactions, serum levels of serotonin （5-HT） , andother aspects of the change and treatment after 3 months back when the patient＇s symptoms, signs, compare the treatment effect of twogroups of patients were observed. Results The total effective rate in the treatment group was 93.3%, which was higher than 80.0% inthe control group （P〈0.05） . The treatment group was superior to the control group in reducing serum5-ht content. There were2cases of adverse reactions in the treatment group and3 cases of adverse reactions in the control group. There was no significantdifference in the incidence of adverse reactions between the groups （P〉0.05） . The recurrence rate of the two groups was statisticallyanalyzed （P〈0.05） , and the treatment group was lower than the control group. Conclusion modified Shengyang Yiwei decoction inthe treatment of diarrhea irritable bowel syndrome has curative effect, can significantly reduce the long-term recurrence rate, noobvious side effects and safe, hasa high clinical value, and is worth popularizing for reference.