海绵状脑病的MRI诊断

MRI diagnosis of creutzfeldt-jakob disease

目的探讨海绵状脑病的MRI特征对该病的诊断价值。方法回顾性分析5例海绵状脑病的临床及影像资料,所有病例均行MRI平扫及增强扫描。结果患者主要临床表现为进行性痴呆和肌阵挛。5例脑电图均有弥漫性异常,出现典型周期性三相波。T1WI和T2WI未见明确异常信号,除了2例脑萎缩。所有患者在DWI出现沿大脑皮质走行、类彩带状的高信号。增强扫描未见明确异常强化灶。结论 DWI皮质彩带状的高信号,是海绵状脑病的主要征象,结合临床表现及脑电图应考虑海绵状脑病。

Objective To analyze MRI of creutzfeldt-jakob disease （CJD） and to evaluate its diagnostic value of this disease. Methods We retrospectively analyzed the clinical data of 5 patients with CJD. All cases were performed unenhanced and enhanced MRI. Results The main clinical manifestations of CJD were progressive dementia and myoclonus. The EEG results were all diffused abnormality and all cases showed periodic three phase waves. No abnormal signals were revealed on T 1WI and T 2WI except nonspecific brain atrophy in 2 cases. The typical features of all cases were cortical ribbon sign on DWI. There was no abnormality on enhanced MRI. Conclusion That cortical ribbon sign on DWI was the most frequent signs of CJD. Based on main clinical manifestations and EEG, CJD should be considered.