双氯芬酸钠联合仙灵骨葆治疗骨性膝关节炎的临床效果

Therapeutic study of knee osteoarthritis treated with Xian Linggubao capsule combined with diclofenac sodium

目的:观察双氯芬酸钠联合仙灵骨葆治疗骨性膝关节炎的疗效及安全性。方法:将120例骨性膝关节炎的患者随机分为西药组60例、联合组60例。西药组患者给予双氯芬酸钠肠溶片,联合组患者同时给予双氯芬酸钠肠溶片和仙灵骨葆胶囊,疗程均为30 d。观察两组患者治疗前后VAS和Lysholm评分;检测两组患者治疗前后前列腺素E2(PGE2)、肿瘤坏死因子-a(TNF-a)的变化;比较两组患者的治疗有效率和不良反应的发生率。结果:治疗后联合组患者的总有效率为96. 7%,高于西药组患者的85. 0%(X^2=8. 526,P=0. 0137)。不良反应的发生率联合组患者为11. 6%,西药组患者为26. 7%(X^2=10. 264,P=0. 0083)。结论:双氯芬酸钠联合仙灵骨葆治疗骨性膝关节炎的疗效优于单独应用双氯芬酸钠,且不良反应的发生率较双氯芬酸钠低。

Objective： To observe the clinical effect and security in the treatment of knee osteoarthritis with Xianlinggubao capsule combined with diclofenac sodium. Methods： 120 cases of knee osteoarthritis were randomly divided into western medicine group and combination group, 60 cases in each group. Western medicine group was treated with diclofenac sodium while the combination group was given Xianlinggubao capsule combined with diclofenac sodium. A course was 30d. The visual analog scale （VAS） and the Lysholm scoring system（Lysholm）were applied to estimate the efficacy of the two group before and after treatment. Changes of prostaglandin E2 （PGE2） and tumor necrosis factor -a （TNF-a） were measured before and after treatment in the two groups. The effective rate and incidence of adverse reactions in the two groups were compared. Results： The total effective rate was 96.7 % in the combined group after treatment, higher than 85.0 % in the western medicine group （χ 2=8.526, P =0.0137）. The incidence of adverse reactions was 11.6% in the combined group and 26.7 % in the western medicine group （χ 2=10.264, P =0.0083）. Conclusion： The efficacy of diclofenac sodium combined with Xianlinggubao capsule in the treatment of osteoarthritis of the knee is better than that of diclofenac sodium alone, with lower incidence of adverse reactions.