阿司匹林联合他汀类药物用于脑血栓形成治疗中对动脉斑块的影响探究

Effect research of Aspirin combined with statins on arterial plaques in the treatment of cerebral thrombosis

目的探究脑血栓形成患者采用他汀类药物与阿司匹林联合治疗的临床价值。方法 36例脑血栓形成患者,遵照随机化分组原则分为参照组和实验组,各18例。参照组患者给予抗血小板药物阿司匹林进行口服治疗,实验组患者在对照组基础上应用他汀类药物治疗。比较两组患者的临床疗效及治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、日常生活活动能力(ADL)评分、斑块面积和内膜-中层厚度(IMT)。结果实验组患者的治疗总有效率66.7%显著高于对照组的33.3%,差异具有统计学意义(P<0.05)。治疗前两组患者的NIHSS评分和ADL评分比较差异无统计学意义(P>0.05);治疗后实验组NIHSS评分低于参照组, ADL评分高于参照组,差异具有统计学意义(P<0.05)。治疗前两组患者的斑块面积和IMT比较差异无统计学意义(P>0.05);治疗后,两组患者的斑块面积和IMT均小于治疗前,且实验组小于参照组,差异具有统计学意义(P<0.05)。结论临床治疗脑血栓形成时采用阿司匹林与他汀类药物治疗效果显著,可积极改善神经功能缺损,提高自我生活能力,减少动脉斑块面积及厚度,临床推广价值高。

Objective To investigate the clinical value of statins combined with Aspirin in the treatment of cerebral thrombosis. Methods A total of 36 patients with cerebral thrombosis were divided into reference group and experimental group according to the principle of randomization, 18 cases in each group. Patients in the reference group were given antiplatelet drugs and Aspirin for oral treatment. Patients in the experimental group were treated with statins on the basis of the control group. The clinical efficacy, the national institutes of health stroke scale （NIHSS） score, activity of daily living （ADL） score, plaque area and intima-media thickness （IMT） before and after treatment between the two groups were compared. Results The total effective rate of the experimental group was 66.7%, which was significantly higher than 33.3% of the control group, the difference was statistically significant （P〈0.05）. There were no significant differences in the NIHSS score and ADL score between the two groups before treatment （P〉0.05）. After treatment, the NIHSS score of the experimental group was significantly lower than that of the reference group, and the ADL score of the experimental group was significantly higher than that of the reference group, the differences were statistically significant （P〈0.05）. There were no significant differences in the plaque area and IMT between the two groups before treatment （P〉0.05）. After treatment, the plaque area and IMT of the two groups were significantly less than those before treatment, and above indexes of the experimental group were significantly less than those of the reference group, the differences were statistically significant （P〈0.05）. Conclusion The curative effect of Aspirin combined with statins in the treatment of cerebral thrombosis is significant, it can improve neurological deficit actively, improve self-living ability, reduce the area and thickness of arterial plaques, it has high clinical value.