临床上非甾体抗炎药不良反应发生病例危险因素分析

Analysis of risk factors for adverse reactions of non-steroidal anti-inflammatory drugs in clinical practice

目的分析临床上使用非甾体抗炎药(NSAIDs)不良反应的危险因素。方法选取80例临床上使用非甾体抗炎药患者作为研究对象,观察其不良反应的发生情况,并分析发生不良反应的危险因素。结果 80例临床上使用非甾体抗炎药患者中,发生不良反应32例,不良反应发生率为40%。经分析,年龄≥60岁、超常剂量、服药时间>3 d均为使用非甾体抗炎药患者发生不良反应的危险因素(P<0.05)。结论应根据患者具体情况使用非甾体抗炎药,尽量避免导致使用非甾体抗炎药发生不良反应的因素,尽量避免产生不良反应。

Objective To analyze the risk factors for adverse reactions of non-steroidal anti-inflammatory drugs （NSAIDs） in clinical practice. Methods A total of 80 patients with NSAIDs in clinical practice were research objects, the incidence of adverse reactions was observed, and the risk factors of adverse reactions were analyzed. Results In the 80 cases of clinical use of non-steroidal anti-inflammatory drugs,adverse reactions occurred in 32 cases, the incidence of adverse reactions was 40%. After analysis, age greater than or equal to 60 years old, supernormal dosage and duration of taking medicine longer than 3 days were the risk factors for adverse reactions in patients with NSAIDs （P〈0.05）. Conclusion Non-steroidal anti-inflammatory drugs should be used according to the specific situation of the patients, and the factors leading to the adverse reactions of non-steroidal anti-inflammatories should be avoided as much as possible, and the adverse reactions should be avoided as much as possible.