TACE术联合LRFA术治疗小肝癌的疗效

Therapeutic effect of TACE combined with LRFA on small liver cancer

目的探讨经肝动脉化疗栓塞术(TACE)联合腹腔镜下射频消融术(LRFA)治疗原发性小肝癌的疗效及生存状态。方法回顾性分析2015年1月至2017年1月在我院接受治疗的60例原发性小肝癌患者的临床资料,对照组(30例)接受LRFA术,联合组(30例)接受TACE术联合LRFA术。比较两组患者的临床资料。结果术后1、2个月,两组患者AFP水平均明显低于术前,且术后2个月,两组患者AFP水平均明显低术后1个月(P<0.05)。联合组的患者不良反应总发生率、术后1年复发率明显低于对照组患者(P<0.05)。结论 TACE术联合LRFA术治疗原发性小肝癌能提高疗效,降低复发率,值得临床借鉴。

Objective To investigate the efficacy and survival status of transcatheter arterial chemoembolization （TACE） combined with laparoscopic radiofrequency ablation （LRFA） in the treatment of primary small hepatocellular carcinoma. Methods The clinical data of 60 patients with primary small hepatocellular carcinoma treated in our hospital from January 2015 to January 2017 were retrospectively analyzed. The control group （30 cases） underwent LRFA and the combine group （30 cases） underwent TACE combined with LRFA. The clinical data of the two groups were compared. Results At 1 and 2 months after surgery, the levels of AFP in the two groups were significantly lower than those before surgery, at 2 months after surgery, the levels of AFP in the two groups were significantly lower than those at 1 months after surgery （P〈0.05）. The total incidence of adverse reactions and the recurrence rate at 1 year after surgery in the combine group were significantly lower than in the control group （P〈0.05）. Conclusion TACE combined with LRFA can improve the curative effect of primary small hepatocellular carcinoma and reduce the recurrence rate, which is worthy of clinical reference.