带状疱疹后发生缺血性脑卒中的危险因素分析

Risk factors analysis of secondary ischemic stroke after herpes zoster

目的探讨带状疱疹后发生缺血性脑卒中的危险因素。方法回顾性纳入2015年1月至2018年6月本院收治的128例带状疱疹患者作为研究对象,将继发缺血性脑卒中患者35例作为试验组,其余93例带状疱疹患者作为对照组。采用单因素和Logistic回归分析带状疱疹后发生缺血性脑卒中的影响因素。结果试验组年龄≥50岁、皮损在头面部的患者占比高于对照组,皮损严重度评分、VAS评分高于对照组,发病至入院治疗时间长于对照组,差异均具有统计学意义(P<0.05);多因素Logistic回归分析结果显示,带状疱疹患者继发缺血性脑卒中与年龄(OR=2.159,95%CI:1.076~4.327,P=0.007)和皮损部位(OR=12.341,95%CI:6.087~17.421,P=0.001)有关。结论水痘-带状疱疹病毒(VZV)感染继发缺血性脑卒中的危险因素有年龄、皮损部位,临床上应加强对带状疱疹后发生缺血性脑卒中的防范意识。

Objective To investigate the risk factors of secondary ischemic stroke after herpes zoster. Methods A total of 128 patients with herpes zoster treated in our hospital from January 2015 to June 2018 were retrospective included as the study objects. Thirty-five patients with secondary ischemic stroke were set as experimental group, and the remaining 93 patients with herpes zoster were set as control group. Influential factors of secondary ischemic stroke after herpes zoster were analyzed by univariate and Logistic regression analysis. Results The proportions of patients with ≥50 years old and skin lesions on the head and face in the experimental group were higher than those in the control group, the severity of skin lesions degree score and VAS score were higher than those in the control group, the time from onset to admission was longer than that in the control group, and the differences were statistically significant （P〈0.05）. Multivariate Logistic analysis results showed that secondary ischemic stroke after herpes zoster was related to age （OR=2.159, 95%CI： 1.076～4.327, P= 0.007） and lesion locations （OR =12.341, 95%C1： 6.087～17.421, P=O.O01）. Conclusion The risk factors of secondary varicella-zoster virus （VZV） infection secondary ischemic stroke include age and skin lesions. Clinically, the prevention of secondary ischemic stroke after herpes zoster should be strengthened.