2型糖尿病并发亚临床甲状腺功能减退的相关因素分析

Analysis of related factors of type 2 diabetes complicated with subclinical hypothyroidism

目的分析2型糖尿病(T2DM)并发亚临床甲状腺功能减退(SCH)的相关因素。方法回顾性分析我院248例T2DM患者的临床资料,对可能引起患者并发SCH的相关因素进行单因素及多因素Logistic回归分析。结果 248例T2DM患者中,有48例发生SCH,发病率为19.35%。甲状腺功能正常组的平均年龄、BMI小于SCH组,病程短于SCH组,双胍类药物使用率高于SCH组,CRP及Cys-C水平低于SCH组(P<0.05)。多因素Logistic回归分析显示,年龄、病程是T2DM患者并发SCH的危险因素,双胍类用药史是保护因素(P<0.05)。结论对于高龄及病程长的T2DM患者,临床应加强甲状腺功能检测。

Objective To analyze the related factors of type 2 diabetes （T2DM） complicated with subclinical hypothyroidism （SCH）. Methods The clinical data of 248 patients with T2DM in our hospital were retrospectively analyzed, and the univariate and multivariate Logistic regression analysis were conducted for the related factors that may cause patients complicated with SCH. Results Among the 248 patients with T2DM, there were 48 cases complicated with SCH, and the incidence rate was 19.35%. The mean age and BMI of the normal thyroid function group were lower than those of the SCH group, the course of disease was shorter than that of the SCH group, and the use rate of biguanide drug was higher than that of the SCH group, CRP and Cys-C levels were lower than those of the SCH group （P〈0.05）. The multivariate Logistic analysis results showed that age and course of disease were risk factors for SCH in patients with T2DM, and the history of biguanide drug use was the protective factor （P〈0.05）. Conclusion For elderly patients and long-term T2DM patients, the thyroid function test should be strengthened clinically.