血清S100β蛋白在孤立性眩晕患者的表达及意义

Expression and clinical significance of serum protein S100β in patients with isolated vertigo

目的 探索血清S100β蛋白在孤立性眩晕患者的表达，分析其在发病早期对急性后循环卒中与非血管性眩晕的鉴别，为临床孤立性眩晕患者的早期诊断和治疗提供可靠依据。方法 以急性孤立性眩晕起病的患者为研究对象，分为卒中组（50例）和非血管性眩晕组（50例），分别测定其在发病24小时内的空腹血清S100β蛋白浓度。结果 卒中组血清S100β蛋白浓度显著高于非血管性眩晕组，差异具有统计学意义（t=6．456，P=0．000）。结论 S100β蛋白可以作为一种血清生物学标记来鉴别以孤立性眩晕起病的急性后循环卒中和非血管性眩晕。

Objective To investigate the expression of serum protein S100β in patients with isolated vertigo, analyze the diagnosis effect on acute posterior circulation stroke and nonvascular vertigo, which provide the evidence for early diagnosis and treatment of isolated vertigo. Methods The patients with acute isolated vertigo were divided into two groups, the stroke group （50 cases） and the nonvascular vertigo group （50 cases） , and the empty serum protein S100β expression levels in 24 hours was tested . Results The levels of serum protein S100β in the stroke group were significantly higher than the nonvascular vertigo group, with a statistical difference （t = 6.456, P = 0.000 ）. Conclusion S100β could serve as a biomarker for distinguishing between acute posterior circulation stroke and nonvascular vertigo.