醋酸亮丙瑞林治疗小儿性早熟的临床分析

Clinical Effect of Leuprorelin Acetate in the Treatment of Children With Precocious Puberty

目的通过对小儿性早熟患者进行治疗时采用醋酸亮丙瑞林治疗方式的应用效果进行分析,探讨其应用价值。方法选取2016年5月—2017年5月到本院来进行治疗的66例小儿性早熟患者作为研究对象。按照随机原则,将其平均分为观察组与对照组,每组各33例。对照组患者采取醋酸甲地孕酮治疗方式,而观察组在对照组基础上,施加醋酸亮丙瑞林治疗方式,对比两组患者的疗效。结果治疗后,观察组患者的各项指标均优于对照组患者,差异均具有统计学意义(P <0.05);观察组患者不良反应总发生率为9.09%,小于对照组的12.12%,但组间比较,差异不具有统计学意义(P> 0.05)。结论在对小儿性早熟患者进行治疗时,醋酸亮丙瑞林效果更好,安全性高。

Objective To explore the application value of leuprorelin acetate in the treatment of children with precocious puberty. Methods 66 cases of children with precocious puberty who came to our hospital from May 2016 to May 2017 were selected as study subjects. According to the principle of randomization, the patients were equally divided into observation group and control group, 33 cases in each group. Patients in the control group were treated with megestrol acetate. On the basis of the control group, the observation group was treated with leuprorelin acetate. The curative effects of the two groups were compared. Results After treatment, the physical indexes of the observation group were better than those of the control group, and the difference was statistically significant （P 〈 0.05）. The incidence of adverse reactions in the observation group was slightly better than that in the control group （9.09% vs. 12.12%）, but the difference was not statistically signifcant （P 〉 0.05）. Conclusion In the treatment of children with precocious puberty, the effect of leuprorelin acetate is better and safer.