双-(N-双(二甲胺基)亚甲基)-氯化亚胺盐的合成及在相转移催化Halex反应中的应用

Synthesis of Bis[N-bis(dimethylamino)methylene]-iminium Chloride and Its Application as Phase Transfer Catalyst in Halex Reaction

N-烷基共轭季铵盐是制备芳香氟化物的一种新型相转移催化剂。以四甲基脲为原料,通过氯代、缩合、中和3步反应合成了双-[N-双(二甲胺基)亚甲基]-氯化亚胺盐(CNC^+Cl^-),通过~1H NMR、^(13)C NMR和热重分析(TG)对其进行结构表征,并将该催化剂应用于Halex反应,获得了比其它常规相催化剂更好的氟化反应结果。

N-Alkyl-conjugated ionic quaternary ammonium salt is a novel phase transfer catalyst for the preparation of fluorinated aromatic compounds.In this article,bis（N-bis（dimethylamino）methylene）-iminium chloride（CNC＋Cl-）was synthesized from tetramethylurea through three step reactions including chlorination,condensation and neutralization.The structure of catalyst was characterized by 1H NMR,13C NMR and thermogravimetric analysis（TG）.It was then used in the Halex reaction so as to result in better results than other conventional catalysts.