摘要
白细胞介素（interleukin，IL）-17A是IL-17家族中功能最强的细胞因子。研究发现，IL-17A参与多种自身免疫炎性疾病的发生和发展，抑制IL-17A可能对这类疾病起治疗作用。随着对IL-17A研究的深人，人们已经开发出针对IL-17A的抗体。苏金单抗作为一种针对IL-17A的生物制剂，在自身免疫病治疗中具有广阔的应用前景。
Interleukin （IL）-17A is the most potent cytokine member of IL-17 family.Studies have shown that IL-17A is involved in the occurrence and development of a variety of autoimmune inflammatory diseases,and inhibitors of IL-17A may play an important role in the treatment of these diseases.With the deepening study of IL-17A,antibodies against IL-17A have been developed.Secukinumab has a promising future in the treatment of autoimmune diseases as a biological agent targeting IL-17A.
作者
李芊(综述)
张进安(审校)
Li Qian;Zhang Jin＇an(Department of Endocrinology,Jinshan Hospital of Fudan University,Shanghai 201508,China)
出处
《国际生物制品学杂志》
CAS
2018年第5期225-229,共5页
International Journal of Biologicals
基金
国家自然科学基金（81471004,81670722）
