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姜辣素对人口腔鳞癌细胞抑制作用的研究 被引量:2

The inhibitory effect of Gingerol on human oral sqaumous cell carcinoma
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摘要 目的观察姜辣素(Gingerol)对人口腔鳞癌细胞系CAL-27恶性生物学行为的影响。方法选取人口腔鳞癌细胞CAL-27细胞系进行培养,用不同浓度的Gingerol处理对数期CAL-27细胞,通过MTT实验检测Gingerol对人口腔鳞癌细胞增殖的影响;克隆形成实验检测Gingerol对人口腔鳞癌细胞的克隆形成能力影响;划痕实验检测Gingerol对人口腔鳞癌细胞的迁移能力的影响; Transwell实验检测Gingerol对人口腔鳞癌细胞的侵袭能力的影响。结果 Gingerol能有效抑制人口腔鳞癌细胞CAL-27的增殖、克隆形成、迁移和侵袭能力,并呈一定的时间和剂量依赖性。结论姜辣素对人口腔鳞癌细胞CAL-27细胞在增殖、克隆和迁移侵袭等恶性生物学行为方面能起到明显的抑制作用,有作为治疗口腔癌药物的应用前景。 Objective To investigate the effect of gingerol on malignant biological behavior of human oral sqaumous cell carcinoma (OSCC) cell line CAL-27. Methods OSCC cell line CAL-27 was cultured in DMEM high glucose medium with 10% FBS and the logarithmic phase CAL-27 cells were treated with different concentrations of gingerol. The effect of gingerol on the proliferation of human oral sqaumous cell carcinoma was detected by MTF assay. The clony formation experiment was conducted to detect the effect of gingerol on human oral sqanmous cell carcinoma. The effect of gingerol on the migration ability of OSCC was examined by scratching assay. Transwell experiment determined the effect of gingerol on the invasion ability of human oral sqaumous cell carcinoma. Results Gingerol could effectively inhibit the proliferation, clone, migration and invasion of OSCC CAL-27, and presented a certain time and dose dependence. Conclusion Gingerol has a significant inhibitory effect on the proliferation, clone formation, migration and invasion of OSCC CAL-27, and may have a promising future in the treatment of oral cancer.
作者 陈素红 宿颖 付洁 张辛燕 CHEN Su-hong;SU Ying;FU Jie;ZHANG Xin-yan(Beijing Institute of Dental Research,Capital Medical University School of Stomatology,Belting 100050,China)
出处 《北京口腔医学》 CAS 2018年第5期246-249,共4页 Beijing Journal of Stomatology
基金 国家自然科学基金(81772868)
关键词 姜辣素 口腔鳞癌 Gingerol Oral sqaumous cell carcinoma
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