摘要
脓毒症终末期发展多为器官功能衰竭及难治性低血压,病死率高、预后不佳。维生素C既是重要的抗氧化剂,也是体内多种酶的辅助因子。目前研究发现维生素C可明显减轻脓毒症炎症反应程度,改善机体微循环和低血压,并有效加强儿茶酚胺类等血管活性药物的效果,防止器官衰竭,改善预后。
Sepsis is frequently associated with multi- system organ dysfunction and refractory hypotension, leading to a high mortality and poor prognosis. As an antioxidant, ascorbie acid (vitamin C) is an important auxiliary factor for many enzymes in the organism. Numerous studies have revealed that vitamin C can attenuate the inflammatory response, improve microcirculatory and hypotension in sepsis, and also can enhance the role of catecholamine in central nervous system, to prevent sepsis-induced organ failure and improve prognosis of patients.
作者
陆世珉
田山
董卫国
Lu Shimin;Tian Shah;Dong Weiguo(Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中华全科医师杂志》
2018年第10期827-829,共3页
Chinese Journal of General Practitioners