中国近10年脂肪肝常见病因的分析

Analysis of common etiology of fatty liver in recent ten years in China

目的分析中国成年人脂肪肝的常见病因。方法检索2008年1月至2017年12月中国知网、万方和维普数据库发布的关于脂肪肝病因的研究,用R软件和Stata软件对患病率、影响因素、血液生化指标进行Meta分析。结果最终纳入24篇研究文献,累计病例共计49 275例。Meta分析结果显示:脂肪肝在人群中的总患病率为19. 31%,男性患病率为26. 44%,女性患病率为15. 31%;在<30岁的患病率为13. 20%,31～40岁的患病率为16. 73%,41～50岁的患病率为20. 98%,51～60岁的患病率为21. 85%,> 60岁的患病率为17. 46%;脂肪肝患者与正常人群比较中各影响因素的风险比分别为高胆固醇2. 03,高三酰甘油3. 02,谷草转氨酶升高3. 70,谷丙转氨酶升高4. 55,高血糖2. 54,肥胖10. 73,喜油腻食物3. 93,常饮酒2. 85,高血压2. 06,体重指数脂肪2. 52;脂肪肝患者中血液生化结果与正常人群相比2组均数的差异分别为总胆固醇1. 23,三酰甘油1. 18,高密度脂蛋白-0. 55,低密度脂蛋白0. 28,谷草转氨酶1. 09,谷丙转氨酶1. 45,总胆红素1. 09,空腹血糖1. 16。结论中国成年人中男性脂肪肝患病率高于女性,常见影响因素主要有高胆固醇、高三酰甘油、谷草转氨酶升高、谷丙转氨酶升高、高血糖、肥胖、喜油腻食物、常饮酒、高血压和体重指数,且脂肪肝患者的血液生化指标与正常人群比均出现异常。

Objective To analyze the common causes of fatty liver in Chinese adults. Methods The CNKI, WANFANG database and VIP database were searched by computer, and the etiology of fatty liver was published from January 2008 to December 2017. Meta - analysis of prevalence, influencing factors, and blood biochemical indicators were performed using R software and Stata software. Results Twenty -four stu- dies were finally included, with a total of 49,275 cases. Meta - analysis showed that the prevalence of fatty liver in the population were： total prevalence 19.31%, male prevalence 26.44%, female prevalence 15.31%. The prevalence rates at different ages were： 〈 30 years old 13.20%, 31 -40 years old 16. 73%, 41 -50 years old 20. 98%, 51 - 60 years old 21.85%, 〉 60 years old 17.46%. The risk ratio of influen- cing factors in patients with fatty liver compared with normal population was ： high cholesterol 2.03, high triglyceride 3.02, aspartate transaminas increased 3.70, alanine transaminase increased 4. 55, hyperglycemia 2. 54, obesity 10. 73, greasy food 3.93, alcohol consumption 2.85, hypertension 2.06, quality index fat 2. 52. The differences in mean blood biochemical results between patients with and without fatty liver were as follows - total cholestero 1.23, triglyceride 1. 18, high - density lipoprotein - 0. 55, low - density lipoprotein 0. 28, aspartate traasaminase 1.09, alanine transaminase 1.45, total bilirubin 1.09, fasting blood glucose 1.16. Conclusion The preva- lence of fatty liver in Chinese men is higher than that in females; common factors are high cholesterol, high triglyeerides, elevated aspartate transaminase, elevated alanine transaminase, hyperglycemia, obesity, greasy food, hypertension, body mass index; patients with fatty liver fatty biochemical indicators than the normal population were abnormal.