126例口腔颌面部间隙感染患者治疗效果相关影响因素分析

Analysis of related factors affecting treatment results in 126 patients with oral and maxillofacial space infection

目的:分析影响口腔颌面部间隙感染治疗效果的相关因素。方法:收集新疆医科大学第一附属医院口腔颌面外科2015—2017年间接受住院治疗的126例口腔颌面部间隙感染患者的一般临床指标(体重指数、发病到入院天数、间隙累及的数量等)、实验室检查指标(白细胞数目、中性粒细胞数目、白介素6、C反应蛋白、降钙素、血糖、血脂及白蛋白等)。采用SPSS20.0软件包对影响因素进行Pearson相关分析,多重线性回归方法分析影响患者住院天数的相关因素。结果:相关性分析发现,患者住院天数与年龄、白细胞、中性粒细胞、中性粒细胞比、C反应蛋白、体重指数(BMI)、甘油三酯、高密度脂蛋白、间隙累及数量显著相关(P<0.05);多重线性回归分析发现4个自变量回归系数具有统计学意义(P<0.05),分别是感染间隙数目、发病至入院天数、甘油三酯、中性粒细胞。结论:口腔颌面部间隙感染患者住院天数与感染累及间隙数量、甘油三酯、炎症细胞及因子量呈正相关变化趋势,与高密度脂蛋白呈负相关变化趋势。此外,感染间隙数量、发病至入院天数、甘油三酯、中性粒细胞对口腔颌面部间隙感染的治疗结果有显著影响。

PURPOSE： This study was aimed to retrospectively investigate the related factors of oral and maxillofacial space infection in 126 patients. METHODS： The clinical data of 126 patients with oral and maxillofacial space infection were collected from the Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University during the period of 2015 to 2017. The clinical features（e.g. body mass index, the number of days from onset to hospital admission, and the number of inflammatory spaces, and etc.） as well as laboratory examination variables（e.g.leucocytic count, the number of neutrophilic granulocyte, interleukin-6, C reactive protein, calcitonin, blood glucose, blood lipids, albumin, and etc.）. Pearson correlation method were used to analyze the correlated factors and multiple linear regression analysis was used to analyze the related factors with SPSS20.0 software package. RESULTS： Correlation analysis showed that there was a significant correlation in the hospitalization days with the ages, white blood cells, neutrophilic granulocyte, neutrophil ratio, C reactive protein, body mass index, triglyceride, high density lipoprotein, the number of inflammatory spaces. The results of multiple linear regression analysis showed that there were 4 independent variables（P〈0.05）, which were the number of inflammatory spaces, the number of days from onset to hospital admission, triglyceride and neutrophilic granulocyte. CONCLUSIONS： There was a positive correlation between the hospitalization days with the number of inflammatory spaces, triglyceride, inflammatory cells and cytokines in patients with oral and maxillofacial space infection. In addition, the related factors affecting the treatment results of oral and maxillofacial space infection include the number of inflammatory spaces, the number of days from onset to hospital admission, triglycerides and neutrophils.