芪苓通络方联合甲泼尼龙与环磷酰胺治疗特发性膜性肾病中高危患者临床观察

Clinical Observation of Combination of Qiling Tongluo Formula,MethylprednisoloneandCyclophosphamide Treating High-risk Patientsof Idiopathic Membranous Nephropathy

目的：观察芪苓通络方联合甲泼尼龙与环磷酰胺治疗特发性膜性肾病中高危患者临床疗效。方法：采用随机、对照的临床研究方法,将80例患者随机分为治疗组和对照组。对照组给予甲泼尼龙＋环磷酰胺,治疗组在对照组基础上予中药汤剂芪苓通络方加味治疗,比较两组患者疗效、24 h尿蛋白定量、血浆白蛋白、肾功能、血脂、纤维蛋白原、D-二聚体等指标的变化。结果：治疗组经6个月治疗后疗效优于对照组（P〈0.05）,24 h尿蛋白定量、纤维蛋白原、D-二聚体均下降,血浆白蛋白升高,与对照组比较差别有统计学意义（P〈0.05）;肾功能、血脂指标均改善,治疗过程中不良反应少。结论：中西医结合方案治疗特发性膜性肾病中高危患者疗效较好,安全性更高。

Objective：The curative effect of the combination of Qiling Tongluo Formula,Methylprednisoloneandcyclophosphamidetreating high-risk patients of idiopathic membranous nephropathy was observed.Methods：By a randomized and comparative research methods,totally 80 patients were randomly divided as the treatment group and control group. The control group was treated by combining ofmethylprednisolone with cyclophosphamide.The treatment group was treated by Qiling Tongluo Formula basedon the control group. The effects, 24 h urinary protein, plasma albumin, renal function, blood fat,fibrinogen and D-dimer were observed before and after treatment.Result：The curative effect of the treatment group was better than that of the control group after treatment（P〈0.05）. 24 h urinary protein, fibrinogen and D-dimer were decreased and ALB was increased after treatment.There were significant differences as compared with those of the control group（P〈0.05）. Renal function and blood fat were improved.Adverse reactions were reduced.Conclusion：The curative effect of the combination of Chinese and western medicine treating high-risk patients of idiopathic membranous nephropathy is better. And its security is high.