补气凉血汤联合米索前列醇治疗产后出血的疗效及对氧化应激和炎症因子的影响

Effect of Supplementing Qi and Cooling Blood Decoction Combined with Misoprostol on Postpartum Hemorrhage and Its Effects on Oxidative Stress and Inflammatory Factors

目的：评价补气凉血汤联合米索前列醇治疗产后出血的疗效及对氧化应激和炎症因子的影响。方法：产后出血患者140例,根据Excel随机表格法分为对照组和治疗组各70例,对照组产妇在分娩后采用米索前列醇联合欣母沛治疗。治疗组产妇分娩后在口服米索前列醇的基础上联合补气凉血汤内服治疗。均治疗两周。比较两组临床疗效、比较两组产妇的出血情况、比较两组产妇治疗前后SOD、LPO和GSH-Px水平、比较两组治疗前后血清炎性因子CRP、TNF-α、IL-8水平。结果：经研究结果显示,治疗组总有效率为95.71%高于对照组总有效率为80.00%（P〈0.05）;治疗组产妇的出血量、出血时间、后期出血率、产褥期感染率均低于对照组（P〈0.05）;治疗后治疗组和对照组患者SOD和GSH-Px水平均显著升高,治疗组高于对照组,且LPO水平明显低于对照组（P〈0.05）;和治疗前相比,两组治疗后血清炎性因子CRP、TNF-α、IL-8水平均有所下降。治疗组治疗后血清炎性因子CRP、TNF-α、IL-8水平低于对照组（P〈0.05）。结论：本研究所用内服中药汤剂补气凉血汤,功效益气凉血、固本培元、活血止血,与米索前列醇联合应用,可以缓解患者血清SOD、LPO和GSH-Px氧化应激水平,降低血清CRP、TNF-α和IL-8炎症因子表达,提高治疗疗效,值得临床推广运用。

Objective： To evaluate the effect of Supplementing Qi and Cooling Blood Decoction combined with misoprostol on postpartum hemorrhage and its effects on oxidative stress and inflammatory factors. Methods： According to the Excel random form, 140 cases of postpartum hemorrhage were divided into the control group and the treatment group. The control group was treated with misoprostol and copperate after delivery. The treatment group was given oral administration of misoprostol combined with Supplementing Qi and Cooling Blood Decoction after delivery. All patients were treated for two weeks. We compared the clinical effect of the two groups, the bleeding of the two groups, the levels of SOD, LPO and GSH-Px before and after treatment, and the levels of serum inflammatory factors CRP, TNF-αand IL-8 before and after treatment. Results：The results showed that the total effective rate of the treatment group was 95.71%,higher than that of the control group（P〈0.05）, and the amount of bleeding, bleeding time, late bleeding rate and puerperium infection rate in the treatment group were all lower than those of the control group（P〈0.05）, and the levels of SOD and GSH-Px in the treatment group and the control group were significantly increased. Tthe level of LPO was significantly lower than that of the control group（P〈0.05）. The serum inflammatory factors CRP, TNF-α and IL-8 in the treatment group and the control group were lower than those beforetreatment. After treatment, the levels of serum inflammatory factors CRP, TNF-α and IL-8 were lower in the treatment group than those in the control group（P〈0.05）. Conclusion：In this study, Supplementing Qi and Cooling Blood Decoction is used in the study. It can relieve the oxidative stress levels of SOD, LPO and GSH-Px in serum, reduce the levels of serum CRP, TNF-α and IL-8 inflammatory factors, and highlight the advantages of the combination of Chinese and Western medicine. The effect is obvious and worthy of clinical promotion and application.