中西医结合治疗胶质瘤疗效及对生活质量的影响

Effect of Combined Treatment of Traditional Chinese Medicine and Western Medicine on Quality of Life of Patients with Glioma

目的：探讨中西医结合治疗胶质瘤患者疗效及对患者生活质量的影响。方法：初治胶质瘤患者82例,按照随机表法分为观察组41例与对照组41例。对照组采用替莫唑胺胶囊治疗,观察组在对照组基础上结合自拟中药汤剂治疗。两组均以21 d为1个疗程,连续服用4个疗程。比较两组疗效,治疗前后主要症状积分、KPS评分、Barthel指数评分、T淋巴细胞亚群变化,及不良反应发生情况。结果：观察组总有效率（87.81%）高于对照组（60.98%）（P〈0.05）;两组治疗后气短、乏力懒言、神疲积分降低（观察组t=18.925、14.696、22.417,对照组t=9.022、9.166、9.734,P〈0.05）;观察组治疗后气短、乏力懒言、神疲积分低于对照组（t=31.461、14.122、14.089,P〈0.05）;两组治疗后KPS评分和Barthel指数评分增加（观察组t=11.089、35.916,对照组t=9.242、9.365,P〈0.05）;观察组治疗后KPS评分和Barthel指数评分高于对照组（t=19.289、42.513,P〈0.05）;两组治疗后CD＋3、CD＋4、CD＋4/CD＋8增加（观察组t=9.168、5.685、9.676,对照组t=11.013、5.335、9.285,P〈0.05）;观察组治疗后CD＋3、CD＋4、CD＋4/CD＋8高于对照组（t=20.571、10.364、18.236,P〈0.05）;观察组恶心、呕吐、腹泻、白细胞减少、血小板下降发生率低于对照组（P〈0.05）。结论：中西医结合治疗胶质瘤患者近期疗效显著,可改善患者生活质量,且不良反应少,用药安全性良好,值得研究。

Objective：To investigate the effect of integrated traditional Chinese and Western medicine on the quality of life of patients with glioma. Methods：82 patients with primary glioma were selected and randomly divided into observation group（41 cases） and control group（41 cases）. The control group was treated with temozolomide capsules and the observation group was treated with self-made Chinese medicine decoction on the basis of the control group. The two groups were treated for 21 d as 1 course,and 4 courses were taken continuously. The main symptom scores,KPS score,Barthel index score,T lymphocyte subsets,and side effects of the two groups were compared before and after treatment. Results： The total efficiency of the observation group（87.81%） was higher than the control group＇s（60.98%）（P〈0.05）. The two groups＇ shortness of breath,fatigue,Shenpi lazy words points were lower after treatment（observation group t=18.925,14.696,22.417,control group t=9.022,9.166,9.734,P〈0.05）. The observation group＇s shortness of breath,fatigue,lazy words spiritlessness points after treatment were lower than that of the control group＇s（t=31.461,14.122,14.089,P〈0.05）. The two groups＇ KPS score and Barthel index score after treatment increased（the observation group t=11.089,35.916,control group t=9.242,9.365,P〈0.05）. The observation group＇s KPS score and Barthel index scores after treatment were higher than the control group＇s（t=19.289,42.513,P〈0.05）. The two groups＇ CD＋3,CD＋4 and CD＋4/CD＋8 after treatment increased（observation group t=9.168,5.685,9.676,control group t=11.013,5.335,9.285,P〈0.05）. The control group＇s CD＋3,CD＋4,CD＋4/CD＋8 after treatment were higher than the control group＇s（t=20.571,10.364,18.236,P〈0.05）. The incidence of nausea,vomiting,diarrhea,thrombocytopenia and thrombocytopenia in the observation group was lower than that in the control group（P〈0.05）. Conclusion：The combination of Chinese and Western medicine treatment of glioma patients in the near future has significant curative effect,and can improve the quality of life of patients,and has less toxic side effects. It is safe,worthy of study.