清化和络剂治疗隆起糜烂性胃炎的临床观察及对循环炎症因子的影响

Qinghua Heluoji in Treatment of Erosive Gastritis and Influence on Circulating Inflammatory Factors

目的：研究清化和络剂治疗隆起糜烂性胃炎的临床效果及对循环炎症因子的影响。方法：90例隆起糜烂性胃炎患者,根据数字表法随机分为3组,即中药组、西药组及联合组,每组各30例。中药组患者给予清化和络剂治疗,西药组患者给予奥美拉唑肠溶片、铝碳酸镁片治疗,联合组患者给予清化和络剂加奥美拉唑肠溶片、铝碳酸镁片治疗。对比3组患者治疗效果、治疗后症状评分、腺体萎缩、肠上皮化生、异型增生以及血清IL-8、TNF-α、IL-10变化情况。结果：联合组患者治疗总有效率（96.67%）明显高于中药组（73.33%）、西药组（66.67%）,差异有统计学意义（P〈0.05）。联合组患者胃脘疼痛、胃脘痞满、口苦口黏或口臭、纳呆食少、胃脘嘈杂不适、反酸、烧心、嗳气评分明显低于中药组、西药组,差异有统计学意义（P〈0.05）。联合组患者治疗后腺体萎缩（3.33%）、肠上皮化生（3.33%）、异型增生发生率（3.33%）明显低于中药组（30.00%、23.33%、20.00%）、西药组（30.00%、33.33%、26.67%）,差异有统计学意义（P〈0.05）。联合组患者治疗后血清IL-8（7.56±1.68）ng/L、TNF-α（1.83±0.32）ng/mL、IL-10水平（6.36±1.25）μg/L明显低于中药组[（13.29±3.23）ng/L、（2.21±0.49）ng/mL、（13.13±3.44）μg/L]、西药组[（15.41±3.45）ng/L、（2.21±0.49）ng/mL、（14.87±3.56）μg/L],差异有统计学意义（P〈0.05）。结论：清化和络剂联合西药治疗隆起糜烂性胃炎疗效显著,可改善临床症状,调节血清学指标水平,简便易行,不良反应较小,易于推广。

Objective： To study the clinical effect of Qinghua Heluoji in the treatment of erosive gastritis and effect on circulating inflammatory cytokines. Methods： Ninety patients with protuberant erosive gastritis were randomly divided into three groups, namely Chinese medicine group, western medicine group and combined group, 30 cases in each group. The Chinese medicine group were treated with Qinghua Heluoji and the western medicine group was given Omeprazole Enteric-coated Tablets and Hydrotalcite Tablets, and the combined group were given Omeprazole Enteric-coated Tablets, Hydrotalcite Tablets and Qinghua Heluoji. After treatment, the symptom score, gland atrophy, intestinal metaplasia, dysplasia and serum IL-8, TNF-alpha and IL-10 changes were compared among three groups. Results： The total effective rate of combined group（96.67%） was significantly higher than those of the Chinese medicine group（73.33%） and western medicine group（66.67%）, and the difference was statistically significant（P〈0.05）. The combined group＇s epigastric pain, epigastric pain, sticky mouth or bad breath, poor appetite, stomach discomfort, noisy regurgitation, heartburn and belching score were significantly lower than those of the traditional Chinese medicine group and western medicine group. The difference was statistically significant（P〈0.05）. After treatment,the combined group＇s incidence of glandular atrophy（3.33%）, intestinal metaplasia（3.33%） and dysplasia（3.33%） was significantly lower than those of the Chinese medicine group（30%, 23.33%, 20%） and western medicine group（30%, 33.33%, 26.67%）, and the difference was statistically significant（P〈0.05）. After treatment,the combined group＇s IL-8（7.56±1.68）ng/L, TNF-alpha（1.83±0.32）ng/mL and IL-10（6.36±1.25）g/L were significantly lower than those of the Chinese medicine group [（13.29±3.23）ng/L,（2.21±0.49）ng/mL,（13.13±3.44）g/L] and western medicine group[（15.41±3.45）ng/L,（2.21±0.49）ng/mL,（14.87±3.56）g/L]. The difference was statistically significant（P〈0.05）. Conclusion： Qinghua Heluoji combined with western medicine treatment of erosive gastritis is significant, and can improve clinical symptoms and regulate the levels of serum markers, simple, with less side effects. It is easy to popularize.